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. 2002 Oct 7;99(21):13873–13877. doi: 10.1073/pnas.212519999

Figure 2.

Figure 2

Locomotor response of Dbh+/− and Dbh−/− mice to amphetamine. Naive mice were placed in activity chambers and injected with vehicle at 90 min and amphetamine at 120 min, and activity was recorded for an additional 4 h. Amphetamine doses were: 1 mg/kg (Dbh+/−, n = 13; Dbh−/−, n = 13) (a); 2 mg/kg (Dbh+/−, n = 32; Dbh−/−, n = 24) (b); 3 mg/kg (Dbh+/−, n = 24; Dbh−/− n = 24) (c); and 5 mg/kg [Dbh+/−, n = 20; Dbh−/−, n = 17, Dbh−/− DOPS + carbidopa (D + C), n = 4] (d). *, P < 0.05 compared to Dbh+/−; †, P < 0.001 compared to Dbh+/−.