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. 2026 Feb 26;17:1741741. doi: 10.3389/fphar.2026.1741741

FIGURE 1.

Figure with multiple panels depicting a scientific study on engeletin and doxorubicin in mice. Panel A shows chemical structures of engeletin and doxorubicin. Panel B outlines the experimental schedule with dosing timelines. Panel C displays mouse heart images and tissue histology (H&E and Masson staining) for control, engeletin, doxorubicin, and combination groups. Panels D-F are bar graphs measuring heart weight to body weight, fibrotic area, and BNP levels. Panel G presents cardiac ultrasound images for each group. Panels H-K show bar graphs for ejection fraction, fractional shortening, and left ventricular dimensions, indicating statistical significance between groups.

ENG alleviates DOX-induced cardiotoxicity in mice. (A) Molecular structure of ENG and DOX. (B) Flow chart of the experimental protocol in vivo. (C) Representative images of gross heart morphology, HE staining and Masson’s staining of mice in each group (n = 5). (D) The ratio of heart weight to body weight (HW/BW) (n = 5). (E) The quantification of myocardial fibrosis area (n = 5). (F) Expression of BNP in the serum of each group of mice (n = 3). (G) Representative image of an M-mode echocardiogram (n = 5). (H–K) Analyses of LVEF, LVFS, LVEDd and LVESd (n = 5). Statistical analysis was performed using one-way ANOVA, followed by Tukey’s post hoc test. *P < 0.05, **P < 0.01, ***P < 0.001.