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. 2026 Feb 26;17:1741741. doi: 10.3389/fphar.2026.1741741

FIGURE 5.

Panel of scientific figures and images depicting bar graphs (A–C, E, F, H, J), a Western blot (D), and fluorescent microscopy images (G, I) that compare control, ENG, DOX, and DOX+ENG groups for markers such as IL-6, IL-1β, Beclin-1, LC3B, and TNF-α in terms of mRNA expression, protein levels, and immunofluorescence intensity, highlighting statistical significance with asterisks and annotated group names.

ENG mitigated DOX-triggered inflammatory and improved autophagy in cardiomyocytes. (A–C) Relative cardiomyocyte mRNA levels of IL-6, IL-β and Beclin-1 (n = 5). (D–F) Western blotting results of Beclin-1 and LC3B in cardiomyocytes and quantitative analysis (n = 6). (G,H) Representative images and quantitative analysis of Beclin-1 immunofluorescence staining in cardiomyocytes (n = 5). (I,J) Representative images and quantitative analysis of TNF-α immunofluorescence staining in cardiomyocytes (n = 4). Statistical analysis was performed using one-way ANOVA, followed by Tukey’s post hoc test. *P < 0.05, **P < 0.01, ***P < 0.001.