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. 2026 Feb 26;17:1741741. doi: 10.3389/fphar.2026.1741741

FIGURE 6.

Scientific figure comprised of multiple panels showing Western blot results, bar graphs, scatter plots, and fluorescence microscopy images, each comparing control, ENG, DOX, DOX+ENG, and DOX+ENG+CC groups. Quantitative and qualitative data illustrate expression levels of phosphorylated and total AMPK, Beclin-1, LC3B, Bax, Bcl-2, as well as apoptosis and oxidative stress assays. Panel labels, molecular weights, and statistical significance indicators are included throughout the figure.

ENG alleviates DOX-induced cardiomyocyte injury through the AMPK pathway. (A,B) Western blotting results and quantitative analysis of p-AMPK and AMPK in mice cardiac tissue (n = 6). (C,D) Western blotting results and quantitative analysis of p-AMPK and AMPK in cardiomyocytes (n = 5). (E–H) Western blotting results of Beclin-1, LC3B, Bax and Bcl-2 in cardiomyocytes and quantitative analysis (n = 5). (I) Flow cytometry of cardiomyocyte apoptosis in each group. (J,K) Representative images and quantitative analysis of DHE staining of cardiomyocytes (n = 6). Statistical analysis was performed using one-way ANOVA, followed by Tukey’s post hoc test. *P < 0.05, **P < 0.01, ***P < 0.001.