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. 2026 Feb 26;17:1741741. doi: 10.3389/fphar.2026.1741741

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Copyright © 2026 Chen, Zhong, Luo, Huang, Tang, Ye, Lei and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diagram illustrating Engeletin inhibiting apoptosis and autophagy dysregulation by activating phosphorylated AMPK, which blocks the Doxorubicin-induced pathway that leads to oxidative stress, mitochondrial damage, and increased inflammatory markers IL-6, IL-1β, and TNF-α. — Revealing the mechanistic pathways underlying the cardioprotective effects of ENG against DOX-induced cardiotoxicity.