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. 2002 Oct 1;99(21):13902–13907. doi: 10.1073/pnas.172511199

Figure 3.

Figure 3

The stargazin PDZ-binding region is required for synaptic, but not extra-synaptic, AMPAR trafficking. (A) Confocal image of a pyramidal cell expressing stargazinΔC-GFP shows its diffuse localization. (Scale bar: 5 μm.) (B and C) Overexpression of stargazinΔC strongly reduces AMPAR EPSCs (n = 54 pairs, P < 1 × 10 −9) while having no effect on NMDAR EPSCs (n = 37 pairs, P = 0.43). (Scale bars, traces: 10 pA, 20 ms.) (D) In contrast, stargazinΔC still dramatically increases responses to bath application of 500 nM AMPA (n = 9 pairs, P = 0.0006).

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