Figure 4.

PSD-95 palmitoylation and PDZ domains are needed to enhance synaptic AMPAR EPSCs. (A) Diagrams showing the domain structure of the various PSD-95 and MAGUK constructs. SH3, Src homology 3; GK, guanylate kinase. (B) Summary graph showing the effects of overexpressing the various constructs on the evoked AMPAR EPSC in simultaneously recorded pairs. For each construct, the normalized response was obtained by dividing the average AMPAR EPSC amplitude in the transfected cells by the average amplitude in paired, untransfected cells. Statistically significant values are marked with asterisks (*, P < 0.05; **, P < 0.01; ***, P < 0.001); the number of paired recordings is listed for each construct. (C) Summary graph showing the effects of these constructs on the NMDAR EPSC.