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. 2026 Mar 10;16:8699. doi: 10.1038/s41598-026-43501-z

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© The Author(s) 2026

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 3 — IGF2BP1 served as an independent prognostic factor for PTC: Analyses of Sequencing Components, Principal Components, Cluster, and Pseudo-Time. (A) The correlation between risk scores and clinicopathological characteristics in patients with PTC from the TCGA database. (B–C) Univariate and multivariate Cox regression analyses confirmed that IGF2BP1 was an independent prognostic factor for PTC. (D) The nomogram score composed of IGF2BP1 level and age could well reflect the OS of PTC patients, and the C-index is 0.931.