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. 2026 Mar 10;16:8699. doi: 10.1038/s41598-026-43501-z

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© The Author(s) 2026

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 6 — Biological role of IGF2BP1 in PTC cells. (A) The mRNA expression levels of IGF2BP1 in NTHY cells and TC lines. (B) The efficiency of B-CPAP, TPC-1 cell lines transfected with oe-NC and oe- IGF2BP1 was validated by qRT-PCR. (C) CCK-8 assays were conducted to observe B-CPAP, TPC-1 cells’ viability after IGF2BP1 overexpression. (D) Comparison of the number of invasive. (E) Clonogenic activities of B-CPAP, TPC-1 by colony formation assays. (F) Comparison of the number of migrated. *represents p < 0.05; ** represents p < 0.01; *** represents p < 0.001.