Table 1.
IC50 values of selected analgesic/antipyretic drugs and NSAIDs
| Drug | IC50, μM
|
||
|---|---|---|---|
| COX-1 | COX-2 | COX-3 | |
| Acetaminophen | >1,000 | >1,000 | 460 |
| Aminopyrine* | >1,000 | >1,000 | 688 |
| Antipyrine | >1,000 | >1,000 | 863 |
| Aspirin | 10 | >1,000 | 3.1 |
| Diclofenac | 0.035 | 0.041 | 0.008 |
| Dipyrone | 350 | >1,000 | 52 |
| Ibuprofen | 2.4 | 5.7 | 0.24 |
| Indomethacin | 0.010 | 0.66 | 0.016 |
| Phenacetin | >1,000 | >1,000 | 102 |
| Caffeine | >1,000 | >1,000 | >1,000 |
| Thalidomide | >1,000 | >1,000 | >1,000 |
All assays were carried out in the presence of 30 μM arachidonic acid.
*
4-dimethylaminoantipyrine.