表 2. In Vitro bacteriostatic effects of combination therapy with Trans-2-decenal and four common antibiotics used in H. pylori eradication treatment.
反-2-癸烯醛与H.pylori根除治疗的4种常用抗生素体外联用抑菌结果
| H. pylori | Antibiotic A | Antibiotic B | MIC/(μg/mL) | FICI | Interaction | ||
| A | B | A + B | |||||
| Irrelevant effect: There is no mutual influence between the two. Synergistic effect: When the two drugs are used together, the overall effect equals the sum of the effects of each drug used alone. | |||||||
| C101 | AMX | Trans-2-decenal | 2 | 16 | 1 + 16 | 1.5 | Irrelevant effect |
| MTZ | Trans-2-decenal | 16 | 16 | 4 + 16 | 1.25 | Irrelevant effect | |
| LEV | Trans-2-decenal | 16 | 16 | 2 + 16 | 1.0625 | Irrelevant effect | |
| CLA | Trans-2-decenal | 32 | 16 | 4 + 16 | 1.25 | Irrelevant effect | |
| R1 | AMX | Trans-2-decenal | 0.0625 | 8 | 0.0039 + 8 | 1.0624 | Irrelevant effect |
| MTZ | Trans-2-decenal | 64 | 8 | 4 + 8 | 1.0625 | Irrelevant effect | |
| LEV | Trans-2-decenal | 16 | 8 | 1 + 8 | 1.0625 | Irrelevant effect | |
| CLA | Trans-2-decenal | 0.0156 | 8 | 0.0005+4 | 0.5313 | Synergistic effect | |
| R24 | AMX | Trans-2-decenal | 0.25 | 16 | 0.0156 + 16 | 1.0625 | Irrelevant effect |
| MTZ | Trans-2-decenal | 32 | 16 | 8 + 8 | 0.75 | Synergistic effect | |
| LEV | Trans-2-decenal | 32 | 16 | 4 + 16 | 1.125 | Irrelevant effect | |
| CLA | Trans-2-decenal | 32 | 16 | 1 + 16 | 1.0625 | Irrelevant effect | |
| ATCC43504 | AMX | Trans-2-decenal | 0.0625 | 16 | 0.0039+16 | 1.0625 | Irrelevant effect |
| MTZ | Trans-2-decenal | 64 | 16 | 32 + 4 | 0.75 | Synergistic effect | |
| LEV | Trans-2-decenal | 0.25 | 16 | 0.0156+16 | 1.0625 | Irrelevant effect | |
| CLA | Trans-2-decenal | 0.03125 | 16 | 0.0020+8 | 0.5624 | Synergistic effect | |