Fig. 3.

2-HG inhibits T-cell activity. 2-HG is exported from cancer cells, whereafter it enters T-cells via SCL13A to inhibit T-cell activation and proliferation. 2-HG attenuates NFAT signaling as well as ornithine biosynthesis. Adapted from [90]. Abbreviations: 2-HG ((R)-2-hydroxyglutarate), SCL13A (sodium-dependent dicarboxylate transporter 3), PLC-γ1 (phospholipase C-gamma 1), IP₃ (inositol-1,4,5-trisphosphate), IP₃R (IP₃ receptor), CRAC (calcium release-activated channels), Orai1 (calcium release-activated calcium channel protein 1), NFAT (nuclear factor of activated T-cells), AMPK (5’ AMP-activated protein kinase), ATP (adenosine triphosphate), ATP5B (ATP synthase subunit beta), ODC1 (ornithine decarboxylase 1). Figure created using BioRender