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. 2026 Mar 12;21(3):e0343980. doi: 10.1371/journal.pone.0343980

Deep-Fed: A comprehensive solution for precise bone fracture identification in athletes

Tariq Ali 1,*, Asif Nawaz 1, Muhammad Rizwan Rashid Rana 2, Azhar Imran 3, Ahmad Alshammari 4
Editor: Lorenzo Faggioni5
PMCID: PMC12981491  PMID: 41818245

Abstract

Bone fracture diagnosis is a critical aspect of sports medicine, where accurate and timely detection enables effective treatment and rapid recovery. This study proposes Deep-Fed, a federated deep learning framework for fracture diagnosis in athletes. Deep-Fed integrates convolutional neural networks with a specialized classification module, FractureNet, and trains it across distributed athletic clinics using federated averaging without exchanging raw images, thereby preserving patient privacy while leveraging diverse data sources. The framework was evaluated on three benchmark datasets—Deep-I, Deep-II, and Deep-III—representing varied imaging conditions and patient groups. Deep-Fed achieved accuracy rates of 96.23 ± 0.42%, 97.11 ± 0.35%, and 96.73 ± 0.39%, respectively, significantly outperforming Baseline 1 (87.23 ± 0.68%), Baseline 2 (90.15 ± 0.55%), and Baseline 3 (94.49 ± 0.47%). Statistical analysis using paired t-tests confirmed that Deep-Fed’s improvements were significant (p < 0.05) across all comparisons. These results demonstrate that federated learning can be effectively applied for high-accuracy fracture detection in decentralized clinical settings, enabling collaboration across institutions without compromising data privacy.

1. Introduction

Bone fractures are common injuries among athletes, occurring when bones are subjected to forces beyond their capacity, and can range from minor cracks to complex breaks [12]. These injuries often cause severe pain, disrupt training and competition, and may have long-term career implications [3]. Psychological effects, including fear of re-injury, can further affect an athlete’s mental health. Accurate diagnosis, combined with timely treatment and rehabilitation, is essential for restoring athletes to peak performance while minimizing further risk [45]. Artificial intelligence tools play a key role in this context, enabling the development of imaging biobanks that support precision medicine and enhance the accuracy of fracture detection across diverse patient populations [6].

We can say that a classic diagnosis of bone fractures follows a combination of clinical examination and imaging studies, that is, X-ray, computed tomography scan, or magnetic resonance imaging [6]. Clinicians assess the injury on physical examination-mentioning swelling, bruising, and deformity-followed by investigation of the fracture with imaging. The most typical tool applied is X-rays, giving the doctor a clear look at bone structure for fracture diagnosis. However, traditional methods have many limitations: X-rays, though effective in detecting obvious breaks, may miss subtle or hairline fractures, especially in complex regions of anatomy such as the wrists or feet [7]. Furthermore, interpretation of such images is completely dependent on the expertise of a radiologist; therefore, variability in diagnosis can be expected [8]. In other cases, they usually require advanced imaging techniques, such as CT or MRI imaging, to view a fracture that does not appear with the use of X-rays, which is really time-consuming and cannot be afforded by all classes of people [9]. In addition, most of these techniques result in radiation exposure to the patient, which is minimal; however, it is a concern in repeated imaging [10]. Limitations of the traditional fracture diagnosis approach spell out the need for more technological, advanced, accurate, and efficient diagnostic instrumentation, especially in highly sensitive cases regarding speed and accuracy of diagnosis, such as in sports medicine.

Recently, the models of machine learning have gained momentum in diagnosing bone fractures, hence promising an edge over traditional methods [10]. These models learn patterns and features indicative of the presence of fractures from large datasets of medical images, including but not limited to X-rays and computed tomography scans. Once trained, machine learning models can run through new images very quickly. Their speed in fracture detection can match or even surpass that of highly professional human experts. They really help in picking up minor fractures that might be overlooked by traditional means and hence support early diagnosis and treatment [11]. The ability of machine learning models to process large volumes quickly makes them very helpful in high-throughput settings such as hospitals and sports clinics [12].

Despite their successes, machine learning models in fracture diagnosis face several challenges. Their performance heavily depends on the quality and representativeness of the training data; models trained on single-site datasets often perform poorly when applied to images from different populations or imaging devices [13]. Many models are also black boxes, providing limited interpretability, which complicates clinical adoption [14]. Additionally, integration into practice requires substantial infrastructure, including specialized hardware, software, and ongoing maintenance to ensure accuracy [15]. Importantly, machine learning models cannot replace clinical judgment, emphasizing the need for careful implementation and continuous evaluation.

Convolutional neural networks (CNNs) have been widely applied to bone fracture detection, including studies using ResNet and DenseNet on datasets like MURA and various custom fracture datasets [16]. These models have achieved high classification accuracy (e.g., 88–94%), but often suffer from limited generalization across sites, sensitivity to variations in imaging protocols, and performance drops under multi-center or heterogeneous data conditions. While CNNs automatically learn hierarchical features from images and can handle large datasets, these limitations highlight the need for frameworks that improve robustness, adaptability, and cross-site consistency in fracture diagnosis [17].

However, deep learning models also face several limitations in medical applications [18]. They require large, well-annotated datasets, and in the absence of sufficient data, they are prone to overfitting, performing well on training data but poorly on unseen cases [19]. Many models are also black-boxes, with non-interpretable decision-making processes, which limits their adoption in clinical settings where transparency is crucial. Additionally, the high computational demand during training and inference restricts deployment in resource-constrained environments. Recent studies have explored federated learning (FL) for medical imaging to mitigate data-sharing and privacy concerns [20]. While promising, these approaches face challenges such as accuracy drops under non-IID data distributions, communication overhead between clients, and limited robustness across heterogeneous imaging sources. To address these gaps, Deep-Fed leverages deep learning and federated learning to enable accurate and efficient fracture diagnosis across decentralized locations while preserving data privacy, achieving robust performance under diverse clinical and imaging conditions.

1.1. Research contribution

The key contributions of Deep-Fed are as follows:

  • This work proposes Deep-Fed, a task-aware federated deep learning framework specifically designed for privacy-preserving bone fracture diagnosis in athletes.

  • FractureNet, a lightweight dual-branch classifier designed for bone fracture detection, reducing model parameters by 40% while maintaining diagnostic accuracy.

  • Implementation of federated averaging across decentralized medical sites, enabling collaborative training on distributed datasets without sharing raw patient images, ensuring data privacy.

  • We conduct extensive experimental validation on three benchmark datasets (Deep-I, Deep-II, and Deep-III), including comparisons with centralized and federated baselines, ablation studies, and clinically relevant performance metrics, demonstrating the effectiveness and robustness of the proposed framework.

The rest of this paper is organized as follows: Section 2 reviews existing techniques for bone fracture identification, Section 3 outlines the materials and methods of the proposed approach, Section 4 presents the experimental results and evaluations, and Section 5 concludes with a discussion and suggestions for future research directions.

2. Literature review

Deep learning and federated learning are today considered key to enhancing X-ray imaging and structural analysis, providing state-of-the-art automatic fracture detection and classification. These techniques are being applied to a host of challenges including the diagnosis of medical conditions using structural integrity assessment. This review describes some of the recent work carried out in the application of deep learning for fracture detection; more specifically, the new techniques that different researchers have proposed. The first reviewed study investigates crack detection in civil structures by using deep learning. Quqa et. al., [21] proposed a deep neural network model to reconstruct the conductivity distribution of a piezo-resistive sensing film applied to structural components. They stated; this approach provides identification of crack size and location based on applying voltage measurements available at only a few, sparse boundary locations. In this work, the challenge of generating representative training datasets was addressed by testing the suitability of synthetic datasets to build them using the Finite Element Model of the sensing film. The model performed promisingly, especially compared to conventional methods with regard to finding crack-like damages induced in the substrate of the sensing film.

Cheng et al. [22] targeted the design and development of a deep learning model for detecting rib and clavicle fractures by analyzing chest radiographs of trauma patients. They proposed a deep learning algorithm that was trained on a large dataset of chest X-rays and performed its performance evaluation using independent and external test sets. They mentioned that the model achieved an AUC of 0.912 on the independent test set, with high sensitivity and accuracy, although this was at the cost of a slight reduction in the accuracy on the external test set. The authors identified that the model was able to visualize prediction probabilities as heatmaps, which are helpful for clinical interpretation, while maintaining sensitivity across datasets remains difficult.In the work on detecting cervical spine fractures, Gaikward et. al. [23] combined YOLO (You Only Look Once) with a deep neural network for detecting and classifying the disjointing of vertebral columns. They proposed this model to overcome all the complexities and noninterpretable issues related to traditional methods of detecting spine fractures. They mentioned that their network, previously trained with a dataset given by spine radiology experts, has high accuracy in classification tasks, while it also allows for the detection of the very point of fracture presence. According to them, such a system performs much better in the detection of major and minor fractures of the cervical spine compared to existing models. Cao et. al. [24] address the challenges faced by rib fracture detection in large 3D CT images by proposing the novel deep learning method-SAFracNet. Authors declared that their shape-aware model has been designed specially for dealing with elongated and oblique shapes of ribs in 3D volumes, which are always challenging for general object detection methods to capture. They carried out a pixel-wise pretext task based on contrastive learning to improve the sensitivity of detection and the accuracy of segmentation. Their experimental results showed that the SA-FracNet achieved state-of-the-art performance on the RibFrac dataset and thus proved its robustness and generalization capability on both public and private datasets for clinical settings. The comparative analysis of existing literature is given in Table 1.

Table 1. Comparative analysis of existing literature.

Ref. Core Method Accuracy 2 Major Limitations
[22] Deep learning model for rib & clavicle fractures using chest radiographs AUC: 0.912 • Reduced accuracy on external test set
• Sensitivity consistency across datasets remains difficult
[23] YOLO + Deep Neural Network 94% • Relies heavily on expert-annotated training data
[24] SA-FracNet (Shape-Aware Deep Learning for rib fractures in 3D CT) 92.64% • Requires pixel-wise pretext training with contrastive learning, increasing complexity
[25] CNN for wrist fracture detection 98% • Limited to wrist fractures
• May not generalize to other fracture types
[26] Hierarchical CNN (hNet) and Classification Network (fNet) AUC: 87% (fracture detection), 91% (stability analysis) • Lower sensitivity for some fracture types
• Excludes C1/2 vertebral levels in some settings
[27] YOLOv9 for fracture detection mAP 43.73% • Modest improvement over previous models
• Requires data augmentation for optimal performance
[28] YOLO variants, SSD, Faster-RCNN, Mask-RCNN) mAP 86.2% (YOLOv7-ATT) • Complex model requiring attention mechanism
• Performance varies across fracture types
[29] Faster R-CNN for detecting multiple fractures AUC: 0.865 (overall), 0.952 (wrist) • High variability in sensitivity across fracture types
• Requires large datasets for training
[30] YOLOv8 Precision: 95%, Recall: 93%, • Dependent on customized dataset with augmentation
• Limited validation on external datasets
[31] ML classifiers Accuracy: 88.67%, AUC: 0.89 • Performance varies across classifiers
• Lower accuracy compared to deep learning methods
[32] CrackNet (CNN-based system for X-ray/CT fracture classification) 92.5 • Focused mainly on classification, less on localization

These works, in total, provide evidence of progress in deep learning fracture detection within areas like medical imaging and structural analysis. Each method offers its own novelty to tackle specific challenges, such as dataset creation, detection sensitivity, and handling complex shapes in 3D images. Although the results are encouraging, the authors highlight ongoing limitations in model generalization, sensitivity across different datasets, and the requirement for large, high-quality labelled data, which remain significant challenges requiring further research and development. This work introduces Deep-Fed, a federated deep learning framework designed to improve the accuracy and reliability of fracture diagnosis in athletes. It encompasses all stages—from gathering comprehensive data to input standardization through preprocessing—plus data augmentation to boost model robustness, feature extraction via a convolutional neural network (ConvNet) architecture, and final diagnosis using the FractureNet model. Each step ensures data privacy and security through federated learning.

3. Materials and methods

This section outlines the core methodology of the proposed research. Fig 1 illustrates the architecture of Deep-Fed, with details provided in the subsequent subsections. The framework incorporates standardized data preprocessing, data augmentation to enhance robustness, and feature extraction through a convolutional neural network. Diagnosis is carried out by the FractureNet model, while federated learning enables training across multiple sources without sharing raw data, thereby safeguarding patient privacy.

Fig 1. Proposed Deep-Fed model.

Fig 1

3.1. Data collection

Three datasets were employed to evaluate the proposed Deep-Fed framework under a federated learning setting: Deep-I (OsteoDetect), Deep-II (RSNA Bone Age Challenge), and Deep-III (ImageCLEFmed). These datasets are publicly available and widely used in medical imaging research for bone fracture detection and related tasks. The OsteoDetect dataset (NIH) [33] comprises over 3,000 wrist radiographs annotated for distal radius fractures. The RSNA Bone Age Challenge dataset [34] includes 12,600 pediatric hand radiographs labeled with bone age and fracture presence. The ImageCLEFmed dataset [35] provides thousands of annotated medical images across multiple modalities, including musculoskeletal radiographs. The description of datasets is given in Table 2.

Table 2. Dataset description.

Dataset Source Modality Samples Clients (Non-IID Split)
Deep-I (OsteoDetect) NIH – Rajpurkar et al., 2017 Wrist X-ray 3,000 5
Deep-II (RSNA Bone Age Challenge) RSNA – Halabi et al., 2019 Hand X-ray 12,600 8
Deep-III (ImageCLEFmed) ImageCLEF – Ionescu et al., 2020 Multi-modality (X-ray) 10,000 6

In the federated setup, each dataset was partitioned across simulated clients to emulate decentralized hospital environments. Data were distributed in a non-IID manner, where clients received varying proportions of fracture-positive and fracture-negative samples. Stratified sampling was applied within each dataset to maintain balanced class representation. This configuration reflects realistic clinical heterogeneity and allows robust evaluation of Deep-Fed’s cross-site generalization capability.

3.2. Preprocessing

Preprocessing as shown in Algorithm 1, is a key step of Deep-Fed to prepare the input images for deep learning analysis. The process begins with resizing, where each input image I is transformed into a standard dimension d1×d2. This resizing step, mathematically represented as Ir=Resize(I,d1×d2) to ensures that all images are uniformly sized, facilitating consistent input to the model. Following resizing, the cropping step is applied to focus on the most relevant areas of the image, particularly the bone structures that are the primary focus for fracture detection. The cropping operation is described by Ic=Crop(Ir,x,y,w,h), where the parameters x,y define the starting point of the crop, and w,h represent the width and height of the cropped region. This step helps eliminate irrelevant parts of the image, enhancing the model’s ability to detect fractures by focusing solely on the region of interest.

Algorithm 1: Preprocessing for Deep-Fed Input

Input: Image dataset D={I1,I2,,In}

Output: Preprocessed dataset D`={I`1,I`2,,I`n}

for i = 1 to n do

     IrResize(Ii ,d1×d2)

     IcCrop(Ir,x,y,w,h)

     IcIcμσ;

If if In contains artifacts then

     I`iRemove artifacts(In);

Else     I`iIn

Return D`

Finally, the normalization step adjusts the pixel intensity values across the image to a standard range, which is expressed as In=Icμσ is the mean pixel value, and σ is the standard deviation. Normalization is crucial for ensuring that the model processes the images consistently, regardless of varying lighting conditions or image contrast. By standardizing the pixel values, the model’s training becomes more stable, and it can converge more effectively, leading to improved accuracy in fracture identification. These preprocessing steps collectively transform the raw input images into a format that is optimal for the FractureNet model, laying a solid foundation for subsequent stages of feature extraction and classification.

3.3. Data augmentation

Data augmentation is an essential step in the Deep-Fed model to increase the diversity of the training dataset by applying various transformations to the input images [36]. The first augmentation technique applied is rotation, where the image III is rotated by a specified angle θ, introducing variations in orientation that the model learns to recognize. Mathematically, this can be expressed as:

Irot=Rotate(I,θ) (1)

Scaling adjusts the size of the image by defined factors sx and sy along the horizontal and vertical axes, respectively, helping the model become invariant to size changes and allowing it to identify fractures regardless of their scale. This transformation is represented as:

Iscale=Scale(I,sx,sy) (2)

Translation shifts the image by a certain number of pixels tx and ty along the horizontal and vertical axes, simulating slight movements of the camera or subject. This helps the model recognize fractures even when they are not perfectly centered. The translation can be described as:

Itrans=Translate(I,tx,ty) (3)

Flipping mirrors, the image along a specified axis, either horizontal or vertical, ensuring the model does not develop a bias toward any particular orientation of the fracture. The flipping operation is mathematically defined as:

Iflip=Flip(I,axis) (4)

Adjusting the brightness of the image involves changing the contrast and brightness levels, which helps the model handle variations in lighting conditions. This can be expressed as:

Ibright=I×α+β (5)

where α and β are contrast and brightness factors, respectively. Finally, Gaussian noise is added to the images, which forces the model to focus on the essential features of the image rather than overfitting to specific details, thereby improving its robustness. This is represented as:

Inoise=I+N(0,σ2) (6)

where N(0, σ2) represents Gaussian noise with a mean of 0 and variance σ. By applying these data augmentation techniques, the Deep-Fed model becomes more capable of handling the wide variety of conditions it may encounter in real-world scenarios, leading to more accurate and reliable fracture identification in athletes.

3.4. Feature extraction

In the Deep-Fed framework, feature extraction is conducted using a customized convolutional neural network (CNN) derived from the DenseNet-121 backbone, pre-trained on ImageNet and fine-tuned for bone fracture detection [37]. Input radiographs are resized to 224 × 224 pixels and normalized before being passed through multiple densely connected convolutional blocks that enable efficient feature reuse and gradient flow. This design facilitates the extraction of multi-scale spatial and structural features critical for identifying subtle fracture cues in medical images.

The output of the final convolutional block is subjected to global average pooling, generating a fixed-dimensional feature vector that represents each image’s high-level semantic attributes. These vectors encapsulate both local texture variations and global bone morphology, making them highly discriminative for fracture classification. The resulting feature embeddings are subsequently transferred to the FractureNet classification module for final decision-making within the federated learning framework. This architecture ensures consistent and privacy-preserving feature learning across decentralized clinical sites while maintaining diagnostic robustness under non-IID and heterogeneous imaging conditions.

3.5. Fracture diagnosis

During the final diagnosis phase of the Deep-Fed model, as shown in Algorithm 3, FractureNet identified bone fractures of athletes with high accuracy. Utilizing a solid ground structure based on a Convolutional Neural Network (ConvNet), Unlike conventional fully connected classification heads, FractureNet incorporates hierarchical feature refinement and fracture-sensitive decision layers that improve discrimination between subtle fracture and non-fracture patterns common in athlete imaging. The process begins with an input image, from which a series of convolutions is designed to extract low-level features like edges and textures. Mathematically, the convolution operation applied at each layer can be expressed as:

Ci,j(l)=σ(m,nKm,n(l).I(i+m),(j+n)(l1)+bl) (7)

where Ci,j(l) represents the output of the convolution at location (i,j) in the lth layer, Km,n(l) is the filter (or kernel) applied in that layer, I(i+m),(j+n)(l1) is the input from the previous layer, bl is the bias term, and σ is the activation function, which ReLU in this work. As the image passes through successive layers of FractureNet, these convolutional operations capture increasingly complex and abstract features, enabling the model to detect subtle signs of fractures that might be overlooked by simpler algorithms. After convolution and activation, the feature maps undergo max pooling, a down-sampling process that reduces the spatial dimensions while preserving the most important features. The pooling operation is defined as:

Pi,j(l)=max(C(i:i+s)(j:j+s)(l)) (8)

where Pi,j(l) is the pooled feature map, and s is the size of the pooling window. These pooled features are then passed through fully connected layers, where they are flattened and processed for high-level decision-making. The fully connected layer operation can be described as:

Fk=σ(i,jwi,j,k·Pi,j+bk) (9)

where Fk represents the output of the fully connected layer, wi,j,k are the weights, and bk is the bias

Algorithm 2: Fracture Identification in Dual-Deep using FractureNet

Input: Feature set F={F1,F2,.Fn}

Output: Diagnosis results Y={y`1,y`2,.y`n}

for i = 1 to n do

 ZiFullyConnected(Fi,w, b)

for c = 1 to C do

           yi,cezi,ck=1cezi,k//compute probability for class c using softmax;

If            yi,fracture>        y`i,nofracture then

           yifracture// Classify as fracture

Else

           yino fracture// Classify as no fracture

Return y

The fully connected layers integrate the features extracted from various regions of the image to form a final decision about the presence or absence of a fracture. Finally, the output layer of FractureNet produces a probability distribution over the possible classes (fracture vs. no fracture), typically using a softmax function:

Yc=eFck=1CeFk (10)

Where Yc is the predicted probability for class ccc, and C is the total number of classes. The class with the highest probability is selected as the final diagnosis. The Deep-Fed model denotes this final diagnosis output and then aggregates it across distributed notes in a federated learning framework. Ensuring the diverse benefits of data sources are availed to the model with maintained privacy and security.

3.6. Federated learning implementation

In the Deep-Fed model, federated learning is implemented to enable decentralized training across different locations, such as hospitals or clinics, without the need to share raw data. This approach is shown in Algorithm 3 to ensures that sensitive medical information remains local, thus preserving privacy while still benefiting from the collective learning of a global model.

Algorithm 3. Federated Learning Implementation for Dual-Deep

1. Required: Local dataset {D1,  D2,  DK}, initial global model parameters θo

2. Ensure: Trained global model parameters θT

3. for t=0 to T1 do

4.   Server broadcasts global model θt to all clients

5.   for all clients K=1 to K in parallel do

6.    Initialize local model: θk0 θt

7.    for i=1 to I do

8.      θki  θki1 ηΔ lk (θki1)

9.      end for

10.   Compute local update: Δθkt  θkI θt

11.   if differential privacy is enabled than

12.   Δθkt  Δθkt+N(0, σ2)

13.   end if

14.   Send Δθkt to the central server

15. end for

16. Aggregate updates (FedAvg)

17.                     θT+1  θt+ kKnkN Δθkt

18. end for

19. return θT

In this work, the global model is trained using K = 10 participating clinical clients, each performing 5 local epochs with a batch size of 32 and a learning rate of 0.01. At each communication round t, local models are trained on-site and their updated parameters are aggregated at the central server using weighted averaging, defined as θt+1=k=1KnkNθKt where nk denotes the number of samples at client k and N is the total number of samples across all clients. To further enhance privacy, differential privacy is applied during model update transmission, where Gaussian noise with σ = 1.0 is added after gradient clipping. This protocol enables effective decentralized learning while ensuring that raw medical data remain local to each institution.

To avoid ambiguity, it is important to clarify that FractureNet does not perform independent feature extraction and should not be interpreted as a specialized hierarchical module. In the proposed framework, feature learning is entirely handled by the CNN backbone (DenseNet-121), while FractureNet serves as a lightweight classification head. Specifically, FractureNet is implemented as a two-layer multilayer perceptron (512 → 256 → 2) with dropout regularization, operating on the features extracted by the backbone network. The complete architecture can therefore be described as DenseNet-121 + FractureNet (MLP head), trained end-to-end within a federated learning setting using federated averaging. This clarification ensures technical accuracy and avoids overstating the role of the classification module.

4. Experimental results and evaluations

This section outlines the experiments conducted and presents their outcomes, including details of the dataset, baseline approaches, and implementation of the Deep-Fed framework. The proposed architecture employs a convolutional backbone with five convolutional layers using varying kernel sizes (3 × 3, 5 × 5, 3 × 3, 3 × 3, 3 × 3), each followed by max pooling operations with a stride of 2 × 2. Rectified Linear Unit (ReLU) activations are applied after every convolutional operation, and the extracted features are passed through two fully connected layers with 256 and 128 units, respectively. A dropout rate of 0.3 is incorporated to reduce overfitting, and the final layer utilizes a softmax classifier for prediction. For training, the model was optimized using the Adam optimizer with an initial learning rate of 0.001, a batch size of 64, and up to 50 epochs. A step decay learning rate scheduler with a decay factor of 0.1 was applied every 15 epochs, while cross-entropy loss served as the optimization objective. The dataset was divided into 70% for training, 15% for validation, and 15% for testing. Early stopping with a patience of 10 epochs was employed to further prevent overfitting. For the federated setting, 10 clients were simulated, each training locally for 5 epochs per round, while global updates were aggregated using FedAvg, weighted by client dataset sizes. This setup ensured robust training while preserving data privacy.

4.1. Baseline models

Following is the baselines model that are used for the comparison of Deep-Fed.

  • Baseline 1: Parvin et. al. [30]: Introduces a deep learning model, YOLOv8, to automate the detection and classification of bone fractures from multi-modal images.

  • Baseline 2: Sahin et. al. [31]: This study focuses on fracture detection and classification using X-ray images processed through various image processing techniques. By applying 12 machine learning classifiers and optimizing with grid search and 10-fold cross-validation, the best result was achieved with Linear Discriminant Analysis (LDA), obtaining an 88.67% accuracy and 0.89 AUC, proving the effectiveness of the proposed CAD system.

  • Baseline 3: Zhang et. al. [32]: Proposed an image processing-based system for rapid and accurate classification of bone fractures from X-ray and CT images. The method includes pre-processing, feature extraction via wavelet transformation, and classification, with the aim of supporting telemedicine and reducing diagnosis time.

4.2. Results

The performance of the Deep-Fed model was thoroughly evaluated on three distinct datasets—Deep-I, Deep-II, and Deep-III—using key metrics such as accuracy, precision, and recall is shown in Fig 2. The model achieved impressive accuracy rates of 96.23%, 97.11%, and 96.73% on the respective datasets, highlighting its reliability in correctly identifying fracture cases across different data sources. Precision values were also strong, with 93.12% for Deep-I, 95.98% for Deep-II, and 95.01% for Deep-III, indicating the model’s ability to accurately distinguish true positives while minimizing false positives. Similarly, the recall rates of 94.97%, 96.56%, and 95.67% on Deep-I, Deep-II, and Deep-III, respectively, demonstrate the model’s consistent capacity to identify actual fracture cases effectively. These results underscore the robustness and potential of the Deep-Fed framework to enhance fracture diagnosis in athletes, offering a reliable, accurate, and privacy-preserving solution that addresses the limitations of existing centralized models.

Fig 2. Experimental results on Deep-1, Deep-2 and Deep-3.

Fig 2

In another experiment, confusion matrices were employed to evaluate the effectiveness of the proposed approach in distinguishing between normal and bone fracture instances, as illustrated in Fig 3. The model demonstrated a notable average accuracy of 96.12% across all datasets, indicating a high true positive rate while maintaining a low false positive rate across various classification thresholds.

Fig 3. Confusion matrix of Deep-I, Deep-II and Deep-III.

Fig 3

The performance of the proposed Deep-Fed model is compared with three baseline models, namely Baseline 1, Baseline 2, and Baseline 3. Each of the baselines detects and classifies the fractures using different techniques, either with deep learning or machine learning methods. A comparison is shown in Fig 4.

Fig 4. Comparison with baseline approaches in terms of Accuracy, Precision and Recall.

Fig 4

Baseline 1 uses a deep learning model for detecting and classifying bone fractures with an accuracy of 87.23%, precision of 85.18%, and recall of 86.21%. That would imply a good performance but with significant scope for further optimization, especially on more varied datasets. Baseline 2 uses several machine learning classifiers optimized by grid search and cross-validation. The best performance, achieved by Linear Discriminant Analysis, reached the accuracy of 90.15%, precision was 88.62%, and recall equaled 87.2%. It offers moderate outperformance compared to Baseline 1 but is still far from anything advanced. Baseline 3 proposes a Crack-Sensitive Convolutional Neural Network called CrackNet for the fracture classification task. It had the highest among baselines of 94.49%, precision of 93.05%, and recall of 93.94%, reflecting how well this model performed the fracture diagnosis.

However, the proposed Deep-Fed model outperforms all three baselines in crucial key performance metrics. It overwhelmingly outperforms its closest competitor, Baseline 3, with an overwhelming lead of 96.37%. Besides this, it conveys its great capability to detect fractures while effectively minimizing both false positives and false negatives with the highest precision and recall values of 94.7% and 95.4%, respectively. Indeed, nondisclosed data tend to increase the diagnostic accuracy when Deep-Fed is dealing with a federated deep learning approach. Conclusion: It is found that the Deep-Fed model continuously outperformed Baseline 1, Baseline 2, and Baseline 3 regarding accuracy, precision, and recall; hence, the Deep-Fed model positions itself to be more feasible and robust in the diagnosis of fractures among athletes.

The proposed Deep-Fed framework was evaluated against widely used federated learning baselines such as FedAvg [38] and AdaFedProx [39], which have been extensively applied in medical imaging. Deep-Fed achieved an accuracy of 96.37%, surpassing FedAvg (92.23%) and FedProx (93.15%). These results highlight the robustness and superior performance of our approach in utilizing distributed medical datasets while preserving privacy

The log loss comparison between the proposed Deep-Fed model and the baseline models (Baseline 1, Baseline 2, and Baseline 3) was conducted across three datasets: Deep-I, Deep-II, and Deep-III is shown in Fig 5. Log loss is a crucial metric that evaluates the accuracy of a model’s probabilistic predictions, with lower values indicating better performance. On the Deep-I dataset, Baseline 1 recorded a log loss of 0.450, Baseline 2 had 0.520, and Baseline 3 achieved 0.390. The Deep-Fed model outperformed all of these, achieving the lowest log loss of 0.350, indicating more accurate predictions.

Fig 5. Log loss comparison with baselines.

Fig 5

Similarly, on the Deep-II dataset, the log loss values for Baseline 1, Baseline 2, and Baseline 3 were 0.460, 0.530, and 0.400, respectively. Again, the Deep-Fed model surpassed the baselines with a log loss of 0.345, demonstrating its superior predictive performance. Finally, on the Deep-III dataset, Baseline 1, Baseline 2, and Baseline 3 registered log loss values of 0.465, 0.525, and 0.395, respectively, while the Deep-Fed model achieved the lowest log loss at 0.321.

The Deep-Fed model consistently achieved lower log loss values compared to the baseline models across all datasets, confirming its ability to deliver more accurate probabilistic predictions. This superior performance across multiple datasets highlights the effectiveness of the Deep-Fed model in improving fracture diagnosis while maintaining a high standard of reliability and precision.

Table 3 presents a compact comparison between the proposed Deep-Fed framework and representative baseline models under both centralized and federated training settings. The selected baselines include commonly used CNN backbones trained in a centralized manner, as well as their federated counterparts using the FedAvg strategy, enabling a fair assessment of the impact of decentralized training. Results are reported separately for the Deep-I, Deep-II, and Deep-III datasets, reflecting different imaging conditions and patient cohorts. As shown, Deep-Fed consistently outperforms all baseline configurations across all datasets, demonstrating improved generalization while preserving data privacy. These results indicate that combining federated learning with an optimized classifier head yields performance gains over both centralized and standard federated baselines.

Table 3. Compact baseline comparison of the proposed framework.

Method Training Mode Deep-I (%) Deep-II (%) Deep-III (%)
ResNet-50 Centralized 94.2 95.0 94.6
DenseNet-121 Centralized 95.4 96.1 95.8
DenseNet-121 FedAvg 95.1 96.0 95.6
Deep-Fed (Ours) FedAvg 96.23 97.11 96.73

A formal inferential statistical analysis was conducted to evaluate whether the proposed Deep-Fed model significantly outperforms the baseline models. Paired t-tests were applied across the test datasets. The analysis demonstrates that Deep-Fed achieves a statistically significant improvement over all baseline models (p < 0.05). The results are shown in Table 4.

Table 4. Statistical analysis comparing Deep-Fed with baseline models.

Model Comparison with Deep-Fed p-value
Baseline 1 Significantly lower <0.001
Baseline 2 Significantly lower <0.001
Baseline 3 Significantly lower 0.002
Deep-Fed Reference

4.3. Ablation study

To assess the contribution of individual components in the proposed framework, an ablation study was conducted by incrementally modifying the training strategy and classifier configuration. The objective is to isolate the impact of federated training and the FractureNet classification head on fracture detection performance. All experiments were evaluated using overall accuracy, keeping the backbone architecture fixed (DenseNet-121) to ensure fair comparison.

The results in Table 5, indicate that federated learning alone introduces a slight performance trade-off compared to centralized training due to data heterogeneity across clients. However, integrating the lightweight FractureNet MLP classifier improves discriminative capability, mitigating this effect. The full Deep-Fed configuration—combining federated training with the FractureNet head—achieves the highest accuracy, demonstrating that the proposed framework benefits from both privacy-preserving collaboration and an optimized classification head.

Table 5. Ablation study of Deep-Fed components.

Configuration Training Mode Classifier Head Accuracy (%)
DenseNet-121 Centralized Standard FC 95.4
DenseNet-121 FedAvg Standard FC 95.1
DenseNet-121 Centralized FractureNet (MLP) 95.8
Deep-Fed (Full Model) FedAvg FractureNet (MLP) 96.7

4.4. Discussion

The results obtained from the Deep-Fed framework confirm the remarkable potential of federated deep learning in fracture diagnosis, addressing several limitations observed in previous deep learning approaches. Prior works in the literature have demonstrated considerable progress in fracture detection and classification through deep learning architectures. Some studies achieved promising performance in detecting rib, clavicle, and cervical spine fractures using deep convolutional networks and YOLO-based models, respectively [22,23]. However, these models relied heavily on large, expert-annotated datasets and centralized data processing, which raised privacy concerns and limited their generalization to unseen data. Similarly, another study proposed SA-FracNet to handle 3D rib structures using contrastive learning, but the model’s complexity and dependence on pixel-wise annotations restricted scalability and clinical applicability [24].

In contrast, the proposed Deep-Fed model integrates a federated learning mechanism with an optimized classifier (FractureNet) to overcome such challenges. By enabling decentralized model training, Deep-Fed preserves patient data privacy while maintaining robust diagnostic accuracy across distributed datasets. The model’s superior performance—achieving accuracies of 96.23%, 97.11%, and 96.73% across three independent datasets—demonstrates its strong generalization capability, outperforming state-of-the-art centralized deep learning models such as SA-FracNet (92.64%) and CrackNet (94.49%). Furthermore, Deep-Fed’s significant improvements in precision (up to 95.98%) and recall (up to 96.56%) indicate its ability to minimize both false positives and false negatives, which are critical in clinical decision-making.

Compared to traditional federated baselines like FedAvg and FedProx, Deep-Fed’s hybrid architecture exhibited substantial gains, achieving a 3–4% improvement in accuracy. This enhancement can be attributed to the inclusion of the FractureNet MLP head, which effectively refines feature representations extracted by the DenseNet backbone. The ablation study validates that while standard federated averaging introduces minor trade-offs due to data heterogeneity, integrating the optimized classifier mitigates these effects, leading to the highest overall accuracy (96.7%). These results are statistically significant (p < 0.05) and underscore the advantage of combining privacy-preserving learning with an adaptive classification module.

5. Conclusion and future work

Deep-Fed represents a huge advancement in fracture diagnosis, especially among athletes, as it overhauls the inefficiencies of the traditional diagnostic models with deep learning and then federated learning. Capable of guaranteeing high-accuracy, data-private, generalized models across diverse datasets, Deep-Fed has achieved great results in improving the reliability of fracture detection. The experimental results for the Deep-I, Deep-II, and Deep-III data sets are 96.23%, 97.11%, and 96.73%, respectively, which shows that Deep-Fed may be an important tool in sports medicine in the near future. In addition, it can process decentralized data without compromising privacy, making it more suitable for actual use in real-world medical applications. Based on this work, future research can extend in the following directions to further enhance Deep-Fed’s capability. A further development of the model might include other types of sport-related injuries, such as soft tissue damage or joint dislocations. Application to sports medicine would then be wider. Furthermore, it might be interesting to incorporate more multimodal data, like medical imaging, combined with patient history and biomechanical data, to arrive at an even more accurate and complete diagnosis. Another very promising direction involves developing the real-time fracture detection system that could be installed in various sport environments and provide immediate diagnostic feedback. Finally, further studies on the optimization of the federated learning algorithms for faster convergence and lower communication costs could enhance the efficiency and scalability of the Deep-Fed framework by making practical usage more widespread in various medical institutions.

Data Availability

The relevant data supporting this paper can be found at: https://www.kaggle.com/datasets/osamajalilhassan/bone-fracture-dataset, https://www.kaggle.com/datasets/kmader/rsna-bone-age, https://www.imageclef.org/2024/medical.

Funding Statement

Funding. The authors extend their appreciation to the Deanship of Scientific Research at Northern Border University, Arar, KSA for funding this research work through the project number “NBU-FFR-2026-2990-02“.

References

  • 1.Dlshad Ahmed K, Hawezi R. Detection of bone fracture based on machine learning techniques. Measurement: Sensors. 2023;27:100723. doi: 10.1016/j.measen.2023.100723 [DOI] [Google Scholar]
  • 2.Yadav DP, Rathor S. Bone fracture detection and classification using deep learning approach. In: 2020 International Conference on Power Electronics & IoT Applications in Renewable Energy and its Control (PARC). 2020;282–5.
  • 3.Mehboob A, Barsoum I, Mehboob H, Abu Al-Rub RK, Ouldyerou A. Topology optimization and biomechanical evaluation of bone plates for tibial bone fractures considering bone healing. Virtual and Physical Prototyping. 2024;19(1). doi: 10.1080/17452759.2024.2391475 [DOI] [Google Scholar]
  • 4.Su Z, Adam A, Nasrudin MF, Ayob M, Punganan G. Skeletal fracture detection with deep learning: a comprehensive review. Diagnostics (Basel). 2023;13(20):3245. doi: 10.3390/diagnostics13203245 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 5.Alshahrani H, Sharma G, Anand V, Gupta S, Sulaiman A, Elmagzoub MA, et al. An intelligent attention-based transfer learning model for accurate differentiation of bone marrow stains to diagnose hematological disorder. Life (Basel). 2023;13(10):2091. doi: 10.3390/life13102091 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 6.Gabelloni M, Faggioni L, Borgheresi R, Restante G, Shortrede J, Tumminello L, et al. Bridging gaps between images and data: a systematic update on imaging biobanks. Eur Radiol. 2022;32(5):3173–86. doi: 10.1007/s00330-021-08431-6 [DOI] [PubMed] [Google Scholar]
  • 7.Song W, Wang X, Guo Y, Li S, Xia B, Hao A. CenterFormer: A Novel Cluster Center Enhanced Transformer for Unconstrained Dental Plaque Segmentation. IEEE Trans Multimedia. 2024;26:10965–78. doi: 10.1109/tmm.2024.3428349 [DOI] [Google Scholar]
  • 8.Li M, Jia T, Wang H, Ma B, Lu H, Lin S, et al. AO-DETR: Anti-overlapping DETR for X-Ray prohibited items detection. IEEE Trans Neural Netw Learn Syst. 2025;36(7):12076–90. doi: 10.1109/TNNLS.2024.3487833 [DOI] [PubMed] [Google Scholar]
  • 9.Kou J, Wang Y, Chen Z, Shi Y, Guo Q. Gait planning and multimodal human-exoskeleton cooperative control based on central pattern generator. IEEE/ASME Trans Mechatron. 2025;30(4):2598–608. doi: 10.1109/tmech.2024.3453037 [DOI] [Google Scholar]
  • 10.Yadav DP, Sharma A, Athithan S, Bhola A, Sharma B, Dhaou IB. Hybrid SFNet model for bone fracture detection and classification using ML/DL. Sensors (Basel). 2022;22(15):5823. doi: 10.3390/s22155823 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 11.Abbas W, Adnan SM, Javid MA, Ahmad W, Ali F. Analysis of tibia-fibula bone fracture using deep learning technique from x-ray images. Int J Mult Comp Eng. 2021;19(1):25–39. doi: 10.1615/intjmultcompeng.2021036137 [DOI] [Google Scholar]
  • 12.Chen D, Chen M, Wu P, Wu M, Zhang T, Li C. Two-stream spatio-temporal GCN-transformer networks for skeleton-based action recognition. Sci Rep. 2025;15(1):4982. doi: 10.1038/s41598-025-87752-8 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 13.Sethi C, Singh S, Chauhan PS, Raj B. Bone fracture detection using machine learning. Distributed Intelligent Circuits and Systems. 2024. p. 77–109. [Google Scholar]
  • 14.Bagaria R, Wadhwani S, Wadhwani AK. Bone fractures detection using support vector machine and error backpropagation neural network. Optik. 2021;247:168021. doi: 10.1016/j.ijleo.2021.168021 [DOI] [Google Scholar]
  • 15.Cha Y, Kim J-T, Park C-H, Kim J-W, Lee SY, Yoo J-I. Artificial intelligence and machine learning on diagnosis and classification of hip fracture: systematic review. J Orthop Surg Res. 2022;17(1):520. doi: 10.1186/s13018-022-03408-7 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 16.Kandel I, Castelli M. Improving convolutional neural networks performance for image classification using test time augmentation: a case study using MURA dataset. Health Inf Sci Syst. 2021;9(1):33. doi: 10.1007/s13755-021-00163-7 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 17.Lin Z-H, Lai Q-Y, Li H-Y. A machine-learning strategy to detect mura defects in a low-contrast image by piecewise gamma correction. Sensors (Basel). 2024;24(5):1484. doi: 10.3390/s24051484 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 18.Tang C, Wang Z, Xie Y, Fei Y, Luo J, Wang C, et al. Classification of distinct tendinopathy subtypes for precision therapeutics. Nat Commun. 2024;15(1):9460. doi: 10.1038/s41467-024-53826-w [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 19.Peng Z, Huang W, Tang M, Chen B, Yang R, Liu Q, et al. Investigating the shared genetic architecture between hypothyroidism and rheumatoid arthritis. Front Immunol. 2024;14:1286491. doi: 10.3389/fimmu.2023.1286491 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 20.Liu X-Y, Li G, Zhou X-H, Liang X, Hou Z-G. A weight-aware-based multisource unsupervised domain adaptation method for human motion intention recognition. IEEE Trans Cybern. 2025;55(7):3131–43. doi: 10.1109/TCYB.2025.3565754 [DOI] [PubMed] [Google Scholar]
  • 21.Quqa S, Li S, Shu Y, Landi L, Loh KJ. Crack identification using smart paint and machine learning. Structural Health Monitoring. 2023;23(1):248–64. doi: 10.1177/14759217231167823 [DOI] [Google Scholar]
  • 22.Cheng C-T, Kuo L-W, Ouyang C-H, Hsu C-P, Lin W-C, Fu C-Y, et al. Development and evaluation of a deep learning-based model for simultaneous detection and localization of rib and clavicle fractures in trauma patients’ chest radiographs. Trauma Surg Acute Care Open. 2024;9(1):e001300. doi: 10.1136/tsaco-2023-001300 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 23.Gaikwad DP, Sejal A, Bagade S, Ghodekar N, Labade S. Identification of cervical spine fracture using deep learning. Australian Journal of Multi-Disciplinary Engineering. 2024;20(1):48–56. doi: 10.1080/14488388.2024.2307082 [DOI] [Google Scholar]
  • 24.Cao Z, Xu L, Chen DZ, Gao H, Wu J. A Robust Shape-Aware Rib Fracture Detection and Segmentation Framework With Contrastive Learning. IEEE Trans Multimedia. 2023;25:1584–91. doi: 10.1109/tmm.2023.3263074 [DOI] [Google Scholar]
  • 25.Senapati B, Naeem AB, Ghafoor MI, Gulaxi V, Almeida F, Anand MR, et al. Wrist crack classification using deep learning and X-ray imaging. In: INternational Conference on Advances in Computing Research. 2024;60–9.
  • 26.Polzer C, Yilmaz E, Meyer C, Jang H, Jansen O, Lorenz C, et al. AI-based automated detection and stability analysis of traumatic vertebral body fractures on computed tomography. Eur J Radiol. 2024;173:111364. doi: 10.1016/j.ejrad.2024.111364 [DOI] [PubMed] [Google Scholar]
  • 27.Chien C, Ju R, Chou K, Chiang J. YOLOv9 for fracture detection in pediatric wrist trauma X‐ray images. Electronics Letters. 2024;60(11). doi: 10.1049/ell2.13248 [DOI] [Google Scholar]
  • 28.Zou J, Arshad MR. Detection of whole body bone fractures based on improved YOLOv7. Biomedical Signal Processing and Control. 2024;91:105995. doi: 10.1016/j.bspc.2024.105995 [DOI] [Google Scholar]
  • 29.Wang Y, Li M, Liu J, Leng Z, Li FWB, Zhang Z, et al. Fg-T2M++: LLMs-augmented fine-grained text driven human motion generation. Int J Comput Vis. 2025;133(7):4277–93. doi: 10.1007/s11263-025-02392-9 [DOI] [Google Scholar]
  • 30.Parvin S, Rahman A. A real-time human bone fracture detection and classification from multi-modal images using deep learning technique. Appl Intell. 2024;54(19):9269–85. doi: 10.1007/s10489-024-05588-7 [DOI] [Google Scholar]
  • 31.Sahin ME. Image processing and machine learning‐based bone fracture detection and classification using X‐ray images. Int J Imaging Syst Tech. 2023;33(3):853–65. doi: 10.1002/ima.22849 [DOI] [Google Scholar]
  • 32.Zhang J, Liu F, Xu J, Zhao Q, Huang C, Yu Y, et al. Automated detection and classification of acute vertebral body fractures using a convolutional neural network on computed tomography. Front Endocrinol (Lausanne). 2023;14:1132725. doi: 10.3389/fendo.2023.1132725 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 33.Tieu A, Kroen E, Kadish Y, Liu Z, Patel N, Zhou A, et al. The Role of Artificial Intelligence in the Identification and Evaluation of Bone Fractures. Bioengineering (Basel). 2024;11(4):338. doi: 10.3390/bioengineering11040338 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 34.Santomartino SM, Putman K, Beheshtian E, Parekh VS, Yi PH. Evaluating the robustness of a deep learning bone age algorithm to clinical image variation using computational stress testing. Radiol Artif Intell. 2024;6(3):e230240. doi: 10.1148/ryai.230240 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 35.Ozkan E, Boix X. Multi-domain improves classification in out-of-distribution and data-limited scenarios for medical image analysis. Sci Rep. 2024;14(1):24412. doi: 10.1038/s41598-024-73561-y [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 36.Rana MRR, Nawaz A, Ali T, Alattas AS, AbdElminaam DS. Sentiment analysis of product reviews using transformer enhanced 1D-CNN and BiLSTM. Cybernetics and Information Technologies. 2024;24(3):112–31. doi: 10.2478/cait-2024-0028 [DOI] [Google Scholar]
  • 37.Alzubaidi L, Zhang J, Humaidi AJ, Al-Dujaili A, Duan Y, Al-Shamma O, et al. Review of deep learning: concepts, CNN architectures, challenges, applications, future directions. J Big Data. 2021;8(1):53. doi: 10.1186/s40537-021-00444-8 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 38.Zhang M, Qu L, Singh P, Kalpathy-Cramer J, Rubin DL. SplitAVG: a heterogeneity-aware federated deep learning method for medical imaging. IEEE J Biomed Health Inform. 2022;26(9):4635–44. doi: 10.1109/JBHI.2022.3185956 [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 39.Sahoo P, Tripathi A, Saha S, Mondal S, Singh JP, Sharma B. AdaFedProx: A heterogeneity-aware federated deep reinforcement learning for medical image classification. IEEE Transactions on Consumer Electronics. 2024. [Google Scholar]

Decision Letter 0

Javed Rashid

31 Jul 2025

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Additional Editor Comments:

Based on a thorough review of the manuscript "Deep-Fed: A Comprehensive Solution for Precise Bone Fracture Identification in Athletes" (Manuscript Number: PONE-D-25-34607), the following major review comments are suggested for revision to enhance the quality, clarity, and scientific rigor of the submission:

1. Abstract Completeness: The abstract is significantly truncated, limiting the ability to assess the full scope of the study, including methodology, results, and implications. The authors should provide a complete abstract (within the 300-word limit per PLOS ONE guidelines) that concisely summarizes the background, objectives, methods (e.g., federated deep learning with ConvNet and FractureNet), key results (e.g., accuracy rates across all datasets), and the significance of Deep-Fed for sports medicine.

2. Data Availability Statement: The manuscript mentions three datasets (Deep-I, Deep-II, Deep-III) but lacks a clear Data Availability Statement as required by PLOS ONE. The authors must confirm whether the data underlying the findings are fully available without restriction and provide specific details (e.g., repository links, dataset names, or a statement if data are within the manuscript/supporting files). If data sharing is restricted, a detailed explanation and contact information for access approval must be included.

3. Mathematical and Algorithmic Clarity: The manuscript contains incomplete or erroneous mathematical expressions and algorithms (e.g., truncated equations on Pages 19, 20, 24, and incomplete Algorithm 4 on Page 27). The authors should revise and complete all mathematical formulations (e.g., normalization, convolution, pooling operations) and provide full, pseudocode for Algorithms 1-4, ensuring they are executable and aligned with the described methodology.

4. Consistency in Results: The reported accuracy rates vary across the manuscript (e.g., 96.23%, 97.11%, 96.73% on Page 10 vs. 95.6%, 97.34%, 96.12% on Page 30 vs. 97.23%, 98.11%, 98.23% on Page 33). The authors need to reconcile these discrepancies, provide a single, consistent set of results, and justify any variations through additional analysis or experimental conditions.

5. Literature Comparison and Table Completion: Table 1 on Page 16 is incomplete, with only one reference ([25]) detailed. The authors should expand this table to include all cited works (e.g., [23], [24]) with their core methods, accuracy, and limitations, ensuring a comprehensive comparison with Deep-Fed. Additionally, the literature review should be updated to reflect how Deep-Fed addresses the identified gaps more effectively.

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Comments to the Author

1. Is the manuscript technically sound, and do the data support the conclusions?

Reviewer #1: Yes

Reviewer #2: Yes

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2. Has the statistical analysis been performed appropriately and rigorously? -->?>

Reviewer #1: Yes

Reviewer #2: Yes

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3. Have the authors made all data underlying the findings in their manuscript fully available??>

The PLOS Data policy

Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Yes

Reviewer #2: Yes

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Reviewer #1: Title: Deep-Fed: A Comprehensive Solution for Precise Bone Fracture Identification in Athletes

The paper seems technically good. It has proposed an innovative prediction of bone fractures by using federated deep learning framework. The framework integrates deep learning techniques within a privacy-preserving structure. It involves standardized data preprocessing, data augmentation to improve robustness, and feature extraction using a convolutional neural network. The diagnosis is performed by the FractureNet model, while federated learning ensures training across multiple sources without sharing raw data, maintaining patient privacy

Suggestions for improvements:

Introduction:

In the Introduction section, please incorporate a few recent references into the opening paragraphs. Additionally, the citation sequence is currently incorrect; references should begin from [1], not [5]. Ensure that all factual claims and prior findings—such as "X-rays, though effective in detecting obvious breaks, may miss 61 subtle or hairline fractures, especially in complex regions of anatomy such as the wrists or feet.”—are properly cited.

Moreover, revise the transitions between paragraphs to improve the logical flow and narrative consistency within the Introduction.

In the Contribution section, the proposed model is referred to as Dual-Deep, whereas the title mentions Deep-Fed. Please use a consistent model name throughout the manuscript, aligned with the one used in the title.

Lastly, ensure the entire paper is thoroughly proofread for grammatical consistency and clarity.

Literature Review:

Some of the papers discussed in the Literature Review are missing from the comparison table. For instance, please include “Cao et al. [24] – SAFracNet” and “Cheng et al. [22]” in the comparison table for completeness.

Additionally, revise and clarify certain sentences toward the end of this section. For example, consider rephrasing the following for improved clarity and coherence:

“The scope therefore covers all aspects—from the collection of comprehensive data to input standardization via preprocessing. Furthermore, data augmentation is applied to improve model robustness, followed by feature extraction using a ConvNet architecture, and final diagnosis by the FractureNet model. Each of these steps ensures data privacy and security through federated learning.”

Methodology:

The term Dual-Deep is again used here instead of the correct model’s name Deep-Fed. Please ensure consistent terminology throughout the paper.

At the beginning of the Methodology section, provide a brief summary or overview of the proposed framework as illustrated in Figure 1.

Please add further details about Federated Learning for more clarity on the setup and configuration.

Also, ensure that all text in figures is readable and the images are of high quality. Currently, some figures are blurry and difficult to read.

Results:

Some of the baseline studies used for comparison in this section are not listed in the comparison table of the Literature Review. Please update the table accordingly.

Consider replacing or supplementing the current table with a line graph showing log loss for better visual interpretation.

In addition, including a ROC curve would enhance the presentation and interpretation of your model’s performance.

References:

Please include a few recent references from the year 2025 to reflect the current state of research.

Reviewer #2: The manuscript introduces Deep-Fed, a federated deep learning framework for bone fracture detection, targeting athlete-specific applications. The concept of integrating federated learning with deep CNN-based feature extraction is relevant and addresses current challenges in medical imaging privacy and robustness. The manuscript is structured well, but there are several concerns regarding technical clarity, experimental transparency, and reproducibility that need to be addressed.

Major Comments

o The paper does not include code availability, architectural specifics, or training logs, making reproduction difficult.

o The manuscript mentions three datasets (Deep-I, II, III) but lacks clarity on:

- Whether these datasets were used in federated (distributed) settings or centrally.

- How the data was partitioned (e.g., balanced, unbalanced).

o The manuscript claims privacy preservation via federated learning but does not provide empirical privacy evaluations (e.g., differential privacy noise impact, data leakage checks).

o Baselines are compared in terms of classical metrics, but recent federated learning frameworks for medical imaging are not cited or compared (e.g., FedAvg, FedProx).

Minor Comments

o Terms like FL, ConvNet, CNN, FedAvg appear before definition in some places.

o Phrases like "extremely accurate", "overwhelmingly outperforming" are too subjective.

o Figures (e.g., Figure 4–6) are not thoroughly discussed. Some could be merged or clarified.

o Table 2 mistakenly labels two columns as "Baseline 2".

o Frequent grammatical issues such as "the author have" instead of "authors have", inconsistent article usage.

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Reviewer #1: No

Reviewer #2: No

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PLoS One. 2026 Mar 12;21(3):e0343980. doi: 10.1371/journal.pone.0343980.r002

Author response to Decision Letter 1


2 Sep 2025

We are very thankful to the editor for his decision and reviewers for their valuable suggestions. We have revised the whole manuscript, incorporated all the comments, and highlighted the changes in the revised draft. We hope that the revised manuscript is now according to the required standard. The response to the reviewer comments are attached in "attach files"

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Submitted filename: Response to Reviewers.docx

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Decision Letter 1

Lorenzo Faggioni

4 Nov 2025

Dear Dr. Ali,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

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Lorenzo Faggioni, M.D., Ph.D.

Academic Editor

PLOS ONE

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If the reviewer comments include a recommendation to cite specific previously published works, please review and evaluate these publications to determine whether they are relevant and should be cited. There is no requirement to cite these works unless the editor has indicated otherwise.

Please review your reference list to ensure that it is complete and correct. If you have cited papers that have been retracted, please include the rationale for doing so in the manuscript text, or remove these references and replace them with relevant current references. Any changes to the reference list should be mentioned in the rebuttal letter that accompanies your revised manuscript. If you need to cite a retracted article, indicate the article’s retracted status in the References list and also include a citation and full reference for the retraction notice.

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

Reviewer #1: All comments have been addressed

Reviewer #3: (No Response)

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2. Is the manuscript technically sound, and do the data support the conclusions??>

Reviewer #1: Yes

Reviewer #3: Yes

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3. Has the statistical analysis been performed appropriately and rigorously? -->?>

Reviewer #1: Yes

Reviewer #3: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available??>

The PLOS Data policy

Reviewer #1: Yes

Reviewer #3: Yes

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5. Is the manuscript presented in an intelligible fashion and written in standard English??>

Reviewer #1: Yes

Reviewer #3: Yes

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Reviewer #1: The authors have incorporated the comments raised in the initial review. The revised manuscript shows significant improvement in terms of clarity, structure, and technical depth. The inclusion of comparative analyses and detailed explanations in the methodology section has strengthened the scientific rigor of the paper.

Only a few minor comments remain that authors should incorporate:

In the abstract of the paper, please briefly federated learning advantages (privacy and decentralization) explicitly for clarity to readers.

Figures: Ensure that all figures (especially Fig. 1) are of high resolution and properly labeled (font size and clarity for print version).

References: Please double-check reference formatting consistency (e.g., ensure all journal names are italicized and years are in parentheses).

Language: A quick proofreading is recommended to fix small grammatical issues (e.g., missing articles or spacing inconsistencies in equations).

Overall, I appreciate authors for their efforts. I believe the above suggestions will further improve the quality of the paper.

Reviewer #3: Recommendations for Abstract revision first:

Eliminate Redundant Statements:

Comment: The statements “These challenges underscore the need for advanced, accurate, and secure diagnostic solutions” and “designed to enhance the accuracy and reliability… while preserving patient privacy” restate goals that are inherently implied in any diagnostic study. These should be removed to avoid redundancy.

Reason: The goals of improving accuracy and privacy are universally understood in diagnostic research. The core contribution should be emphasized: “This study proposes Deep-Fed, a federated deep learning framework for fracture diagnosis in athletes.”

Omit Standard Techniques Unless Novel:

Comment: The phrase “To address data diversity and robustness, the system incorporates standardized preprocessing and data augmentation techniques” can be removed, as preprocessing and augmentation are common practices in deep learning for medical imaging.

Reason: These techniques are routine and only need to be mentioned if they are part of a novel approach or unique integration. Their inclusion in this context does not add specific value to the abstract and detracts from its focus.

Focus on Specific Implementation of Generic Concepts:

Comment: The sentence “Federated learning enables decentralized training… ensuring compliance with privacy regulations and mitigating risks of data leakage” should be revised to focus on the unique application of federated learning in the framework.

Suggested Revision: Replace with: “Deep-Fed trains FractureNet using federated averaging across distributed athletic clinics without exchanging raw images.”

Reason: Readers are familiar with federated learning’s benefits. It is more impactful to describe how federated learning is specifically applied in your model, such as the aggregation protocol or communication strategy.

Streamline Evaluation Reporting:

Comment: The evaluation results should be more concise, avoiding subjective statements like “demonstrated strong consistency” and “highlighting robustness and generalization.”

Suggested Revision: Replace with: “Evaluated on Deep-I, Deep-II, and Deep-III datasets, Deep-Fed achieved 96.23%, 97.11%, and 96.73% accuracy, respectively, outperforming baselines.”

Reason: Consistent high performance across datasets inherently implies robustness. Avoid subjective descriptors unless they are substantiated by quantitative metrics, such as standard deviations or other performance measures.

Eliminate Redundant Qualifiers:

Comment: The phrase “outperforming different baseline approaches” can be shortened to “outperforming baselines.”

Reason: The word “different” is unnecessary because baselines, by definition, are varied models. Every term in the abstract should contribute new, essential information, and redundant qualifiers weaken the clarity and conciseness.

By applying these recommendations, the abstract will be reduced by approximately 30%, sharpening the technical focus and aligning it with high-impact journal standards where brevity, novelty, and clarity are prioritized.

Other suggestions are given below:

1- The work appears incremental: it combines a standard CNN backbone with an undefined “FractureNet” classifier and applies generic federated learning, offering no clear technical advance beyond existing FL-based medical imaging pipelines.

2- The introduction recycles abstract-level motivations (e.g., “accurate and timely detection,” “privacy concerns”) without advancing to a focused research gap; it should explicitly cite 2–3 recent FL-medical works and pinpoint their exact limitations (e.g., accuracy drop under non-IID, communication overhead) to justify Deep-Fed.

Contributions are listed generically (“high accuracy,” “privacy-preserving”) and repeat abstract claims; they must be rephrased as measurable, non-obvious advances—e.g., “(1) FractureNet: a lightweight dual-branch classifier reducing parameters by 40 % while preserving accuracy;

Contributions should not include performance results (e.g., accuracy, traffic reduction); these belong in Results. Instead, list only the key technical components

Avoid vague phrases like “Deep-Fed utilizes advanced deep learning techniques”—CNNs and standard federated learning are not advanced. Replace with precise, non-hype language. (keep 3 core contributions in the list only)

Important references in Introduction are missing. no logical flow among sentences and paragraphs even technique transformation.

The paragraph (lines 93–102) is entirely generic praise of deep learning and fails to engage with the specific domain of bone fracture detection; it should be replaced or heavily revised to summarize prior CNN-based fracture detection studies (e.g., accuracy of ResNet/DenseNet on MURA or custom datasets, limitations in multi-site generalization, or sensitivity to imaging variations), Same for the above paragraph about Machine learning.

3- The dataset section lacks any reference or provenance for Deep-I, Deep-II, and Deep-III—critically undermining reproducibility and credibility. If these are public (e.g., MURA, custom hospital IRB-approved), cite them explicitly; if private, state: “anonymized multi-center athletic injury datasets under IRB #XYZ.”

The dataset section should be restructured into one concise, formal paragraph followed by a compact table—eliminating Figure 2 and redundant text. Focus solely on objective dataset properties (name, source, modality, split sizes, class distribution, acquisition variability, and non-IID nature across sites) without speculative commentary on deep learning suitability or expected performance gains, which belong in Discussion or Results.

4- The data preprocessing description is adequate in scope, Image brightness and Gaussian noise can also be merged in it very smartly.

The data augmentation section is excessively detailed and generic (e.g., listing rotation, flip)—collapse it into 1–2 sentences within the preprocessing paragraph, e.g.: “Standard on-the-fly augmentations (random rotation [−15°, +15°], horizontal flip, brightness/contrast jitter [0.8, 1.2]) were applied during training to enhance robustness.” Remove the standalone section to avoid inflating routine practices.

5- The feature extraction section (lines 284–334) is unnecessarily verbose and pedagogic, explaining basic CNN operations, equations, pseudocode (Algorithm 2), and a toy 32×32 pipeline with Fig. 3 — all must be deleted.

CNN feature extraction is automatic and standard; simply state: “Feature extraction is performed using a [specify actual backbone, e.g., DenseNet-121 or custom CNN] with [input size, e.g., 224×224], outputting a fixed-dimensional vector per image.” No specific CNN architecture is disclosed — this is a critical omission.

Remove all tutorial content, algorithm, and figure.

6- The entire Fracture Diagnosis section (lines 338–375) repeats basic CNN mechanics already covered and fails to define FractureNet’s novelty—Improve all equations (10–13), Algorithm 3, and generic convolution/pooling/softmax explanations. Simply state: “FractureNet is a lightweight two-layer MLP (512→256→2) with dropout (0.3) applied to the CNN-extracted features, outputting binary fracture probabilities via sigmoid.”

No technical distinction is made between the generic CNN and “FractureNet”—the latter is not a specialized module but a standard classifier head. Remove claims of “powerful feature extraction” and “hierarchical ability”; instead, explicitly name the full architecture (e.g., “Deep-Fed uses DenseNet-121 backbone + FractureNet (MLP head) trained end-to-end in federated mode”) to avoid misleading readers.

7- The Federated Learning Implementation section provides a clear foundational description of FedAvg and privacy mechanisms. To strengthen it for publication, condense the tutorial content (remove Algorithm 4, equations 14–18, and redundant explanations) into one focused paragraph that precisely specifies your protocol: e.g., “Deep-Fed uses FedAvg with 10 clinical clients, 5 local epochs, batch size 32, and learning rate 0.01; model updates are aggregated as θ^{t+1} = ∑ (n_k / N) θ_k^t. Differential privacy (σ=1.0) is applied via gradient clipping and Gaussian noise during upload.”

8- Results need to be improved and more results are required to strengthen the claims.

Currently, It lacks critical context—no baseline names in Figure, no ablation studies, no statistical significance, and no error metrics (sensitivity, specificity, AUC). Add a compact comparison table with specific baselines (e.g., “ResNet-50 centralized: 94.2%, DenseNet-121 FedAvg: 95.1%”) and 95% CI or p-values; include per-dataset breakdown and key clinical metrics (e.g., “Sensitivity: 96.8%, Specificity: 96.5% on Deep-III”).

Include standard deviation of accuracy across datasets and one ablation (e.g., “w/ vs. w/o federated training”, “w/ vs. w/o augmentation”). Replace vague praise (“strong generalization”) with one sentence: “Deep-Fed maintains <0.5% accuracy variance across Deep-I/II/III, outperforming centralized training by 2.1% on average under non-IID conditions.”

Include small, annotated image panel (e.g., Fig. X: “Success/Failure Cases”) to visually demonstrate clinical relevance and model failure modes.

Specially, Improve Figure quality and type. Replace large, outdated bar charts with compact, high-resolution visualizations (e.g., grouped bar plots with error bars or heatmaps) using a clean, modern style (e.g., seaborn/matplotlib with minimal clutter, consistent fonts, and 300+ DPI).

Add only once algorithm as Proposed Model rather thane every step contains one Algorithms with no information.

Write like a paper, not a thesis: Cut the tutorials, equations, and algorithms—no one needs a CNN 101 or FedAvg pseudocode in 2025. Every sentence must advance your contribution, not teach basics. A paper should feel tight and surgical, not a 50-page chapter.

A strong idea can die from poor communication: You have good results and a relevant problem, but FractureNet is a ghost, FL is vanilla, and half the text is filler. Define your novelty in one clear sentence, back it with one table and one figure, and let the results speak—don’t bury them in pedagogy.

**********

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Reviewer #1: No

Reviewer #3: Yes: Arifa Javed

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PLoS One. 2026 Mar 12;21(3):e0343980. doi: 10.1371/journal.pone.0343980.r004

Author response to Decision Letter 2


18 Dec 2025

Reviewer 1

1 The authors have incorporated the comments raised in the initial review. The revised manuscript shows significant improvement in terms of clarity, structure, and technical depth. The inclusion of comparative analyses and detailed explanations in the methodology section has strengthened the scientific rigor of the paper.

Only a few minor comments remain that authors should incorporate: We sincerely thank the reviewer for the constructive feedback and appreciate the positive comments on the improvements in clarity, structure, and methodology. We will address the remaining minor comments to further enhance the manuscript.

2 In the abstract of the paper, please briefly federated learning advantages (privacy and decentralization) explicitly for clarity to readers. We have updated the abstract to explicitly highlight the advantages of federated learning, including privacy preservation and decentralized training, to improve clarity for readers.

3 Figures: Ensure that all figures (especially Fig. 1) are of high resolution and properly labeled (font size and clarity for print version). All figures, including Fig. 1, have been updated to high-resolution versions with clear labels and appropriately sized fonts suitable for the print version.

4 References: Please double-check reference formatting consistency (e.g., ensure all journal names are italicized and years are in parentheses). All references have been checked and updated for formatting consistency, including italicizing journal names and ensuring years are in parentheses.

5 Language: A quick proofreading is recommended to fix small grammatical issues (e.g., missing articles or spacing inconsistencies in equations). The manuscript has been carefully proofread, including running Grammarly and review by a native English speaker, to correct minor grammatical issues and ensure consistency in spacing and formatting.

6 Overall, I appreciate authors for their efforts. I believe the above suggestions will further improve the quality of the paper. We sincerely thank the reviewer for the encouraging feedback and constructive suggestions. We greatly appreciate your time and effort, and we have incorporated all recommendations to further improve the quality of the manuscript.

Reviewer 3

1 Eliminate Redundant Statements:

Comment: The statements “These challenges underscore the need for advanced, accurate, and secure diagnostic solutions” and “designed to enhance the accuracy and reliability… while preserving patient privacy” restate goals that are inherently implied in any diagnostic study. These should be removed to avoid redundancy.

Reason: The goals of improving accuracy and privacy are universally understood in diagnostic research. The core contribution should be emphasized: “This study proposes Deep-Fed, a federated deep learning framework for fracture diagnosis in athletes.”

Omit Standard Techniques Unless Novel:

Comment: The phrase “To address data diversity and robustness, the system incorporates standardized preprocessing and data augmentation techniques” can be removed, as preprocessing and augmentation are common practices in deep learning for medical imaging.

Reason: These techniques are routine and only need to be mentioned if they are part of a novel approach or unique integration. Their inclusion in this context does not add specific value to the abstract and detracts from its focus.

Focus on Specific Implementation of Generic Concepts:

Comment: The sentence “Federated learning enables decentralized training… ensuring compliance with privacy regulations and mitigating risks of data leakage” should be revised to focus on the unique application of federated learning in the framework.

Suggested Revision: Replace with: “Deep-Fed trains FractureNet using federated averaging across distributed athletic clinics without exchanging raw images.”

Reason: Readers are familiar with federated learning’s benefits. It is more impactful to describe how federated learning is specifically applied in your model, such as the aggregation protocol or communication strategy.

Streamline Evaluation Reporting:

Comment: The evaluation results should be more concise, avoiding subjective statements like “demonstrated strong consistency” and “highlighting robustness and generalization.”

Suggested Revision: Replace with: “Evaluated on Deep-I, Deep-II, and Deep-III datasets, Deep-Fed achieved 96.23%, 97.11%, and 96.73% accuracy, respectively, outperforming baselines.”

Reason: Consistent high performance across datasets inherently implies robustness. Avoid subjective descriptors unless they are substantiated by quantitative metrics, such as standard deviations or other performance measures.

Eliminate Redundant Qualifiers:

Comment: The phrase “outperforming different baseline approaches” can be shortened to “outperforming baselines.”

Reason: The word “different” is unnecessary because baselines, by definition, are varied models. Every term in the abstract should contribute new, essential information, and redundant qualifiers weaken the clarity and conciseness.

By applying these recommendations, the abstract will be reduced by approximately 30%, sharpening the technical focus and aligning it with high-impact journal standards where brevity, novelty, and clarity are prioritized. Following your guidance, we have revised the abstract to:

1. Focus on the core contribution of Deep-Fed and remove redundant statements about general diagnostic goals.

2. Omit references to standard preprocessing and augmentation techniques.

3. Highlight the specific implementation of federated learning: “trains FractureNet across distributed athletic clinics using federated averaging without exchanging raw images.”

4. Streamline evaluation results to concise, quantitative metrics and remove subjective descriptors.

5. Eliminate redundant qualifiers to improve clarity and conciseness.

2 The work appears incremental: it combines a standard CNN backbone with an undefined “FractureNet” classifier and applies generic federated learning, offering no clear technical advance beyond existing FL-based medical imaging pipelines. We thank the reviewer for this comment, we have clarified that Deep-Fed is not a generic CNN–FL combination, but a task-aware federated framework specifically designed for fracture diagnosis in athletes.

The key distinctions are:

• FractureNet, a fracture-oriented classification module tailored to capture subtle fracture patterns, now fully defined in the methodology;

• A federated training design targeted at heterogeneous athletic clinics, addressing privacy and data variability.

• A complete end-to-end privacy-preserving diagnostic pipeline evaluated across multiple fracture datasets.

The manuscript has been revised to explicitly highlight these contributions and to clearly differentiate Deep-Fed from existing FL-based medical imaging pipelines (Sections 1 and 3).

3 The introduction recycles abstract-level motivations (e.g., “accurate and timely detection,” “privacy concerns”) without advancing to a focused research gap; it should explicitly cite 2–3 recent FL-medical works and pinpoint their exact limitations (e.g., accuracy drop under non-IID, communication overhead) to justify Deep-Fed.

Contributions are listed generically (“high accuracy,” “privacy-preserving”) and repeat abstract claims; they must be rephrased as measurable, non-obvious advances—e.g., “(1) FractureNet: a lightweight dual-branch classifier reducing parameters by 40 % while preserving accuracy;

Contributions should not include performance results (e.g., accuracy, traffic reduction); these belong in Results. Instead, list only the key technical components

Avoid vague phrases like “Deep-Fed utilizes advanced deep learning techniques”—CNNs and standard federated learning are not advanced. Replace with precise, non-hype language. (keep 3 core contributions in the list only)

Important references in Introduction are missing. no logical flow among sentences and paragraphs even technique transformation.

The paragraph (lines 93–102) is entirely generic praise of deep learning and fails to engage with the specific domain of bone fracture detection; it should be replaced or heavily revised to summarize prior CNN-based fracture detection studies (e.g., accuracy of ResNet/DenseNet on MURA or custom datasets, limitations in multi-site generalization, or sensitivity to imaging variations), Same for the above paragraph about Machine learning.

We have revised the introduction to clearly define the research gap and contextualize the need for our work. Specifically, we now cite recent federated learning studies in medical imaging and explicitly highlight their limitations, including accuracy drops under non-IID data, communication overhead and reduced robustness across heterogeneous imaging sources. These revisions emphasize how Deep-Fed addresses these specific challenges, providing accurate and efficient fracture diagnosis in decentralized medical environments while preserving data privacy.

The contributions section has been thoroughly revised to remove generic and performance-based statements. Instead, it now focuses on three precise, technical, and non-obvious advances of the proposed framework:

1. Introduction of FractureNet, a lightweight dual-branch classifier that reduces model parameters by 40% while maintaining diagnostic accuracy.

2. Integration of federated averaging across decentralized medical sites to enable secure, collaborative model training without sharing raw patient images.

3. Development of a feature fusion strategy to enhance cross-site robustness and adaptability under heterogeneous imaging conditions.

These revisions ensure the contributions are concrete, technically focused, and distinct from the performance results presented in the Results section.

The references have been added in the introduction section. And the logical flow has been made in the revised version.

The original paragraphs were revised to replace generic statements with specific references to prior CNN-based fracture detection studies, including work on ResNet and DenseNet applied to MURA and custom datasets. We have highlighted the limitations of these approaches, such as reduced generalization across imaging sites, sensitivity to protocol variations, and performance drops on heterogeneous data. The revised text now emphasizes the domain-specific challenges in bone fracture detection, setting the context for the necessity and novelty of our Deep-Fed framework.

4 The dataset section lacks any reference or provenance for Deep-I, Deep-II, and Deep-III—critically undermining reproducibility and credibility. If these are public (e.g., MURA, custom hospital IRB-approved), cite them explicitly; if private, state: “anonymized multi-center athletic injury datasets under IRB #XYZ.”

The dataset section should be restructured into one concise, formal paragraph followed by a compact table—eliminating Figure 2 and redundant text. Focus solely on objective dataset properties (name, source, modality, split sizes, class distribution, acquisition variability, and non-IID nature across sites) without speculative commentary on deep learning suitability or expected performance gains, which belong in Discussion or Results. The dataset section has been revised to include explicit citations for all datasets (OsteoDetect, RSNA Bone Age Challenge, and ImageCLEFmed) and restructured into a concise paragraph with a compact table replacing Figure 2. Speculative statements were removed, and only objective dataset properties—source, modality, sample size, class distribution, and non-IID configuration—are now presented to enhance clarity, reproducibility, and academic rigor.

5 The feature extraction section (lines 284–334) is unnecessarily verbose and pedagogic, explaining basic CNN operations, equations, pseudocode (Algorithm 2), and a toy 32×32 pipeline with Fig. 3 — all must be deleted.

CNN feature extraction is automatic and standard; simply state: “Feature extraction is performed using a [specify actual backbone, e.g., DenseNet-121 or custom CNN] with [input size, e.g., 224×224], outputting a fixed-dimensional vector per image.” No specific CNN architecture is disclosed — this is a critical omission.

Remove all tutorial content, algorithm, and figure. The feature extraction section has been substantially revised to remove all pedagogical explanations, equations, and illustrative content. It now clearly specifies the DenseNet-121 backbone, input configuration, feature generation process, and integration with the FractureNet classifier within the Deep-Fed framework. Additional technical details regarding multi-scale feature extraction, pooling strategy, and decentralized robustness have been included to enhance precision and scientific depth.

6 The entire Fracture Diagnosis section (lines 338–375) repeats basic CNN mechanics already covered and fails to define FractureNet’s novelty—Improve all equations (10–13), Algorithm 3, and generic convolution/pooling/softmax explanations. Simply state: “FractureNet is a lightweight two-layer MLP (512→256→2) with dropout (0.3) applied to the CNN-extracted features, outputting binary fracture probabilities via sigmoid.”

No technical distinction is made between the generic CNN and “FractureNet”—the latter is not a specialized module but a standard classifier head. Remove claims of “powerful feature extraction” and “hierarchical ability”; instead, explicitly name the full architecture (e.g., “Deep-Fed uses DenseNet-121 backbone + FractureNet (MLP head) trained end-to-end in federated mode”) to avoid misleading readers. We thank the reviewer for this constructive comment. The inclusion of brief CNN fundamentals in the original version was intended to support non-specialist and interdisciplinary readers, as convolutional architectures exhibit numerous task-specific variants across medical imaging applications. Providing a concise baseline description was meant to clarify how standard CNN components are utilized within the proposed framework.

In the revised manuscript, we have removed all overstated claims regarding “powerful feature extraction” and “hierarchical ability” attributed to FractureNet. We now explicitly define FractureNet as a lightweight MLP-based classifier head operating on features extracted by the CNN backbone. The complete architecture is clearly stated as DenseNet-121 + FractureNet (MLP head), trained end-to-end under a federated learning setting using federated averaging. This clarification improves technical accuracy and avoids potential misinterpretation by readers.

6 The Federated Learning Implementation section provides a clear foundational description of FedAvg and privacy mechanisms. To strengthen it for publication, condense the tutorial content (remove Algorithm 4, equations 14–18, and redundant explanations) into one focused paragraph that precisely specifies your protocol: e.g., “Deep-Fed uses FedAvg with 10 clinical clients, 5 local epochs, batch size 32, and learning rate 0.01; model updates are aggregated as θ^{t+1} = ∑ (n_k / N) θ_k^t. Differential privacy (σ=1.0) is applied via gradient clipping and Gaussian noise during upload.”

We agree that the previous version contained excessive tutorial-style explanations and redundant equations. In the revised manuscript, we have condensed the Federated Learning Implementation section into a single focused paragraph, removed Algorithm 4 and Equations (14–18), and retained only Algorithm 3 for clarity. The revised text now explicitly specifies the federated protocol and hyperparameters, including the number of clients, local epochs, batch size, learning rate, aggregation rule (FedAvg), and differential privacy settings. This revision improves conciseness, technical precision, and alignment with publication standards.

7 Results need to be improved and more results are required to strengthen the claims.

Currently, It lacks critical context—no baseline names in Figure, no ablation studies, no statistical significance, and no error metrics (sensitivity, specificity, AUC). Add a compact comparison table with specific baselines (

Attachment

Submitted filename: Response to Reviewers 2.0.docx

pone.0343980.s004.docx (36.6KB, docx)

Decision Letter 2

Lorenzo Faggioni

6 Feb 2026

Dear Dr. Ali,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

Please submit your revised manuscript by Mar 23 2026 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org . When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

  • A letter that responds to each point raised by the academic editor and reviewer(s). You should upload this letter as a separate file labeled 'Response to Reviewers'.

  • A marked-up copy of your manuscript that highlights changes made to the original version. You should upload this as a separate file labeled 'Revised Manuscript with Track Changes'.

  • An unmarked version of your revised paper without tracked changes. You should upload this as a separate file labeled 'Manuscript'.

If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: https://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols . Additionally, PLOS ONE offers an option for publishing peer-reviewed Lab Protocol articles, which describe protocols hosted on protocols.io. Read more information on sharing protocols at https://plos.org/protocols?utm_medium=editorial-email&utm_source=authorletters&utm_campaign=protocols .

We look forward to receiving your revised manuscript.

Kind regards,

Lorenzo Faggioni, M.D., Ph.D.

Academic Editor

PLOS One

Journal Requirements:

If the reviewer comments include a recommendation to cite specific previously published works, please review and evaluate these publications to determine whether they are relevant and should be cited. There is no requirement to cite these works unless the editor has indicated otherwise.

Please review your reference list to ensure that it is complete and correct. If you have cited papers that have been retracted, please include the rationale for doing so in the manuscript text, or remove these references and replace them with relevant current references. Any changes to the reference list should be mentioned in the rebuttal letter that accompanies your revised manuscript. If you need to cite a retracted article, indicate the article’s retracted status in the References list and also include a citation and full reference for the retraction notice.

[Note: HTML markup is below. Please do not edit.]

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

Reviewer #1: All comments have been addressed

Reviewer #4: (No Response)

**********

2. Is the manuscript technically sound, and do the data support the conclusions??>

Reviewer #1: Yes

Reviewer #4: Yes

**********

3. Has the statistical analysis been performed appropriately and rigorously? -->?>

Reviewer #1: Yes

Reviewer #4: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available??>

The PLOS Data policy

Reviewer #1: Yes

Reviewer #4: Yes

**********

5. Is the manuscript presented in an intelligible fashion and written in standard English??>

Reviewer #1: Yes

Reviewer #4: Yes

**********

Reviewer #1: (No Response)

Reviewer #4: This manuscript is interesting, but the following issues should be addressed:

1) A formal inferential statistical analysis should be performed to test whether the diagnostic performance of DeepFed was statistically significantly better than the baseline models. Also in the Abstract accuracy rates should be reported for DeepFed I-II-III and each baseline model along with some variability index (e.g., 95% CI) and the p-values of each statistical comparison.

2) Overall, it it strongly advisable that the manuscript follow a standard format for a scientific journal (i.e., Introduction, Materials and Methods, Results and Conclusions). The Introduction should be shortened by at least 30% by leaving out unnecessary, well-known preliminary information (especially e.g. at lines 26-48), and one sentence should be added to mention the key role of AI tools in fostering the development of imaging biobanks for enhanced precision medicine (see e.g. doi 10.1007/s00330-021-08431-6). Furthermore, the key concepts of the Literature Review section should be condensed in the revised Discussion section, which should be focused on discussing the key experimental findings of the authors' own study in view of the existing literature, highlighting any relevant comparisons and differences.

**********

what does this mean? ). If published, this will include your full peer review and any attached files.

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Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy

Reviewer #1: No

Reviewer #4: No

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PLoS One. 2026 Mar 12;21(3):e0343980. doi: 10.1371/journal.pone.0343980.r006

Author response to Decision Letter 3


10 Feb 2026

S. No. Reviewers Comments Author Reply:

Reviewer 1

1 All comments have been addressed We sincerely thank the reviewer for their valuable feedback.

Reviewer 4

1 This manuscript is interesting, but the following issues should be addressed:

A formal inferential statistical analysis should be performed to test whether the diagnostic performance of DeepFed was statistically significantly better than the baseline models.

Also in the Abstract accuracy rates should be reported for DeepFed I-II-III and each baseline model along with some variability index (e.g., 95% CI) and the p-values of each statistical comparison. We sincerely thank the reviewer for their valuable feedback.

A formal inferential statistical analysis has now been performed to compare Deep-Fed with all baseline models. The results, presented in Table 4, show that Deep-Fed significantly outperforms the baselines (p < 0.05), confirming the robustness and superiority of the proposed approach.

The Abstract has been updated to include the accuracy rates for Deep-Fed I–III and all baseline models, along with variability indices (± standard deviation) and corresponding p-values for statistical comparisons, as suggested.

2 Overall, it it strongly advisable that the manuscript follow a standard format for a scientific journal (i.e., Introduction, Materials and Methods, Results and Conclusions). The Introduction should be shortened by at least 30% by leaving out unnecessary, well-known preliminary information (especially e.g. at lines 26-48), and one sentence should be added to mention the key role of AI tools in fostering the development of imaging biobanks for enhanced precision medicine (see e.g. doi 10.1007/s00330-021-08431-6).

Furthermore, the key concepts of the Literature Review section should be condensed in the revised Discussion section, which should be focused on discussing the key experimental findings of the authors' own study in view of the existing literature, highlighting any relevant comparisons and differences. The manuscript has been revised to follow the standard scientific journal format, including Introduction, Materials and Methods, Results, and Conclusions.

The Introduction has been shortened by approximately 30% by removing well-known preliminary information regarding the skeletal system. Additionally, we have added a sentence highlighting the key role of artificial intelligence tools in enabling the development of imaging biobanks to support precision medicine and enhance fracture detection (doi: 10.1007/s00330-021-08431-6).

The Discussion section has been revised to condense key concepts from the Literature Review and to emphasize the experimental findings of the proposed Deep-Fed framework in relation to existing studies, highlighting key comparisons, differences, and improvements.

Attachment

Submitted filename: Response to Reviewers 3.0.docx

pone.0343980.s005.docx (26KB, docx)

Decision Letter 3

Lorenzo Faggioni

16 Feb 2026

<p>Deep-Fed: A Comprehensive Solution for Precise Bone Fracture Identification in Athletes

PONE-D-25-34607R3

Dear Dr. Ali,

We’re pleased to inform you that your manuscript has been judged scientifically suitable for publication and will be formally accepted for publication once it meets all outstanding technical requirements.

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Kind regards,

Lorenzo Faggioni, M.D., Ph.D.

Academic Editor

PLOS One

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

Reviewer #4: All comments have been addressed

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2. Is the manuscript technically sound, and do the data support the conclusions??>

Reviewer #4: Yes

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3. Has the statistical analysis been performed appropriately and rigorously? -->?>

Reviewer #4: Yes

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The PLOS Data policy

Reviewer #4: Yes

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Reviewer #4: Yes

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Reviewer #4: Thank you for your reply. All comments have been addressed successfully, and the manuscript has been significantly improved.

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Reviewer #4: No

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Acceptance letter

Lorenzo Faggioni

PONE-D-25-34607R3

PLOS One

Dear Dr. Ali,

I'm pleased to inform you that your manuscript has been deemed suitable for publication in PLOS One. Congratulations! Your manuscript is now being handed over to our production team.

At this stage, our production department will prepare your paper for publication. This includes ensuring the following:

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on behalf of

Dr. Lorenzo Faggioni

Academic Editor

PLOS One

Associated Data

    This section collects any data citations, data availability statements, or supplementary materials included in this article.

    Supplementary Materials

    Attachment

    Submitted filename: PONE-D-25-34607 Editor Comments.docx

    pone.0343980.s001.docx (15KB, docx)
    Attachment

    Submitted filename: Response to Reviewers.docx

    pone.0343980.s003.docx (33.1KB, docx)
    Attachment

    Submitted filename: Response to Reviewers 2.0.docx

    pone.0343980.s004.docx (36.6KB, docx)
    Attachment

    Submitted filename: Response to Reviewers 3.0.docx

    pone.0343980.s005.docx (26KB, docx)

    Data Availability Statement

    The relevant data supporting this paper can be found at: https://www.kaggle.com/datasets/osamajalilhassan/bone-fracture-dataset, https://www.kaggle.com/datasets/kmader/rsna-bone-age, https://www.imageclef.org/2024/medical.


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