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. Author manuscript; available in PMC: 2005 Dec 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2005 Jul;25(7):1524–1525. doi: 10.1161/01.ATV.0000168913.25278.38

Figure 1.

Figure 1

Panel A. Representative immunoblots showing the formation of thrombin B-chain, prethrombin 2 and prothrombin fragment 1+2 (F1+2) in panel A, and in panel B, the formation of factor Va heavy chain (FVaHC) and FVa inactivation. Consecutive 30-second blood samples, collected from standardized skin incisions, were separated on a 4 to 12% linear gradient SDS-PAGE gel under reducing conditions. Three products, seen in panel A, were probed with a burro polyclonal antibody, which recognizes prethrombin 2, fragment 2, and thrombin B-chain. The bands in panel B were stained with a murine monoclonal antibody against FVaHC (residues 307 to 506). Molecular standards were marked on the left. Lines A –samples collected prior to simvastatin administration; lines B – samples taken after 3 doses of simvastatin (40 mg/d).