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. 2026 Feb 6;18:61. doi: 10.1186/s13195-026-01969-x

Table 1.

Characteristics of the MYHAT-NI cohort

Characteristic Overall
N = 1111
Aβ-PET negative
N = 831
Aβ-PET positive
N = 281
p-value2
Sex 0.2
 Female 60 (54%) 42 (51%) 18 (64%)
 Male 51 (46%) 41 (49%) 10 (36%)
Age 76 (72, 80) 75 (71, 79) 79 (74, 83) 0.052
APOE < 0.001
 Carrier 18 (16%) 6 (7.2%) 12 (43%)
 Not carrier 93 (84%) 77 (93%) 16 (57%)
Education (years) 12.0 (12.0, 16.0) 12.0 (12.0, 16.0) 12.5 (12.0, 15.0) 0.7
Self-identified racial identity > 0.9
 Black/African American 6 (5.4%) 5 (6.0%) 1 (3.6%)
 Non-Hispanic White 105 (95%) 78 (94%) 27 (96%)
CDR 0.016
 0 101 (91%) 79 (95%) 22 (79%)
 0.5 10 (9.0%) 4 (4.8%) 6 (21%)
Tau-PET Status < 0.001
 Negative 72 (65%) 63 (76%) 9 (32%)
 Positive 39 (35%) 20 (24%) 19 (68%)
Pittsburgh N Status 0.10
 Negative 41 (37%) 27 (33%) 14 (50%)
 Positive 70 (63%) 56 (67%) 14 (50%)
Mayo N Status 0.5
 Negative 78 (70%) 57 (69%) 21 (75%)
 Positive 33 (30%) 26 (31%) 7 (25%)
Lumipulse p-tau217 (pg/ml) 0.13 (0.09, 0.19) 0.12 (0.09, 0.16) 0.23 (0.19, 0.40) < 0.001
 (Missing) 3 2 1
ALZPath p-tau217 (pg/ml) 0.39 (0.27, 0.55) 0.34 (0.22, 0.44) 0.71 (0.56, 0.88) < 0.001
 (Missing) 1 1 0
NULISA p-tau217 (pg/ml) 12.44 (12.09, 12.79) 12.30 (12.03, 12.54) 13.08 (12.76, 13.40) < 0.001
Johnson and Johnson p-tau217 (pg/ml) 0.052 (0.037, 0.074) 0.046 (0.035, 0.060) 0.086 (0.067, 0.106) < 0.001
 (Missing) 18 13 5

1n (%), Median (Q1, Q3)

2Pearson’s Chi-squared test, Wilcoxon rank sum test, Fisher’s exact test