Table 2.
Characteristics of the HCP cohort
| Characteristic | Overall N = 2341 |
Negative N = 1991 |
Positive N = 351 |
p-value2 |
|---|---|---|---|---|
| Sex | 0.002 | |||
| Female | 149 (65%) | 135 (69%) | 14 (41%) | |
| Male | 81 (35%) | 61 (31%) | 20 (59%) | |
| (Missing) | 4 | 3 | 1 | |
| Age | 62 (56, 70) | 60 (56, 67) | 72 (68, 79) | < 0.001 |
| (Missing) | 4 | 3 | 1 | |
| APOE | 0.14 | |||
| Carrier | 69 (30%) | 55 (28%) | 14 (40%) | |
| Not carrier | 164 (70%) | 143 (72%) | 21 (60%) | |
| (Missing) | 1 | 1 | 0 | |
| Education (years) | 14.0 (12.0, 17.0) | 14.0 (12.0, 16.0) | 16.0 (14.0, 18.0) | < 0.001 |
| (Missing) | 4 | 3 | 1 | |
| Race | 0.001 | |||
| Asian | 3 (1.3%) | 3 (1.5%) | 0 (0%) | |
| Black/African American | 120 (52%) | 112 (57%) | 8 (24%) | |
| Other | 1 (0.4%) | 1 (0.5%) | 0 (0%) | |
| Non-Hispanic White | 106 (46%) | 80 (41%) | 26 (76%) | |
| (Missing) | 4 | 3 | 1 | |
| MoCA | 25.0 (23.0, 27.0) | 25.0 (23.0, 27.0) | 26.0 (23.0, 27.0) | 0.6 |
| (Missing) | 4 | 3 | 1 | |
| N Status | 0.10 | |||
| Negative | 149 (64%) | 131 (66%) | 18 (51%) | |
| Positive | 85 (36%) | 68 (34%) | 17 (49%) | |
| ALZPath p-tau217 (pg/ml) | 0.25 (0.18, 0.37) | 0.23 (0.17, 0.31) | 0.52 (0.41, 0.81) | < 0.001 |
| (Missing) | 6 | 5 | 1 | |
| Johnson and Johnson p-tau217 (pg/ml) | 0.035 (0.026, 0.049) | 0.033 (0.025, 0.044) | 0.070 (0.049, 0.105) | < 0.001 |
| (Missing) | 30 | 25 | 5 |
1n (%), Median (Q1, Q3)
2Pearson’s Chi-squared test, Wilcoxon rank sum test, Fisher’s exact test