Abbreviation	Definition
AAV	Adeno-associated virus
ACG	Angle-closure glaucoma
AGE	Advanced glycation end-product
AMD	Age-related macular degeneration
AMPK	AMP-activated protein kinase
BBB	Blood–brain barrier
bEND.3	Brain endothelial cell line clone 3
BRB	Blood–retinal barrier
BREC	Bovine retinal endothelial cell
Cldn	Claudin
CNV	Choroidal neovascularization
COH	Chronic ocular hypertension
CTRP3	C1q/tumor necrosis factor-related protein 3
DVL-1	Disheveled-1
DR	Diabetic retinopathy
EC	Endothelial cell
ECL1/2	Extracellular loop 1/2
ER	Endoplasmic reticulum
ERD	Exudative retinal detachment
EV	Extracellular vesicle
FHHNC	Familial hypomagnesemia with hypercalciuria and nephrocalcinosis
FZD4	Frizzled-4 receptor
H&E	Hematoxylin and eosin
HG	Hyperglycemia/High glucose
HREC	Human retinal endothelial cell
ICAM-1	Intercellular adhesion molecule-1
IFN-γ	Interferon-gamma
IL	Interleukin
ILM	Inner limiting membrane
INL	Inner nuclear layer
IOP	Intraocular pressure
IR	Ischemic retinopathy
IRD	Inherited retinal degeneration
iBRB	Inner blood–retinal barrier
iBREC	Immortalized bovine retinal endothelial cell
JAM	Junctional adhesion molecule
LNP	Lipid nanoparticle
LPS	Lipopolysaccharide
LRP5/6	Low-density lipoprotein receptor-related protein 5/6
MAPK	Mitogen-activated protein kinase
miRNA	MicroRNA
NF-κB	Nuclear factor kappa-light-chain-enhancer of activated B cells
NO	Nitric oxide
NPDR	Non-proliferative diabetic retinopathy
NVU	Neurovascular unit
OAG	Open-angle glaucoma
OIR	Oxygen-induced retinopathy
OLM	Outer limiting membrane
ONL	Outer nuclear layer
oBRB	Outer blood–retinal barrier
PDR	Proliferative diabetic retinopathy
PDZ	Postsynaptic density protein domain
PKC	Protein kinase C
POS	Photoreceptor outer segment
PTM	Post-translational modification
PVR	Proliferative vitreoretinopathy
RD	Retinal detachment
RGC	Retinal ganglion cell
RhoA	Ras homolog family member A
RNA-seq	RNA sequencing
ROCK	Rho-associated kinase
ROP	Retinopathy of prematurity
RP	Retinitis pigmentosa
RPE	Retinal pigment epithelium
RT-qPCR	Reverse transcription quantitative polymerase chain reaction
S1P	Sphingosine-1-phosphate
S1PR	Sphingosine-1-phosphate receptor
siRNA	Small interfering RNA
SQSTM1 (p62)	Sequestosome 1
STZ	Streptozotocin
TEER	Trans-epithelial/-endothelial electrical resistance
TGF-β	Transforming growth factor-beta
TJ	Tight junction
TNF-α	Tumor necrosis factor-alpha
TRD	Tractional retinal detachment
VE-cadherin	Vascular endothelial cadherin
VEGF	Vascular endothelial growth factor
Wnt	Wingless-related integration site
W/D	Wet-to-dry ratio
ZO-1/ZO-2/ZO-3	Zonula occludens-1/-2/-3