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. 2026 Mar 1;27(5):2318. doi: 10.3390/ijms27052318
USP Ubiquitin-specific protease
DUB Deubiquitinating enzyme
PTM Post-translational modification
CKD Chronic kidney disease
HGNC Human Genome Nomenclature Committee
UBP Ubiquitin-Specific Processing Protease
UBD Ubiquitin-binding domain
ZnF-UBP Zinc-finger ubiquitin binding protein
DUSP USP-specific protease domains
UBL Ubiquitin-like domains
DNMT1 DNA methyltransferase 1
WDR WD40-repeats
LAP Latent-related peptide
LTBP latent TGF-β-binding protein
TGF-β1 Transforming Growth Factor- β 1
ECM extracellular matrix
TβRI TGF-β type I receptor
TβRII TGF-β type II receptor
STRAP Serine-Threonine Kinase Receptor-Associated Protein
GEF Guanine nucleotide exchange factor
EMT Epithelial-to-mesenchymal transition
TCF4 Transcription factor T cell factor 4
TRAF6 Tumor necrosis factor receptor-related factor 6
UBI2 Unique ubiquitin-like domain 2
IκBα NF-κB inhibitor protein
Ang II Angiotensin II
NLRP3 NOD-, LRR- and pyrin domain-containing protein 3
ROS Reactive oxygen species
SOD2 Superoxide Dismutase 2
ACSL4 Long-chain acyl-CoA synthase
UBI2 Ubiquitin-like domain 2
PDK1 Pyruvate dehydrogenase kinase 1
FN Fibronectin
α-SMA α-smooth muscle actin
AGEs Advanced glycation end products
FGF2 Fibroblast growth factor 2
IRI Ischemia–reperfusion injury
RTECs Renal tubular epithelial cells
HIF-1α Hypoxia-Inducible Factor 1-α
EGFR Epidermal Growth Factor Receptor
SASP Senescence-Associated Secretory Phenotype
Tfap2α Transcription factor AP-2α
TBK1 TANK-binding kinase 1
KLF4 Krüppel-like factor 4
DKD Diabetic nephropathy
UUO Unilateral ureteral obstruction
PROTACs Proteolysis Targeting Chimeras
TXNDC5 thioredoxin domain containing 5