Skip to main content
. 2026 Mar 6;18(5):856. doi: 10.3390/cancers18050856
ADC Antibody–Drug Conjugate
ALK Anaplastic Lymphoma Kinase
ATC Anaplastic Thyroid Carcinoma
BRAF B-Raf Proto-Oncogene, Serine/Threonine Kinase
CDx Companion Diagnostic
CI Confidence Interval
CNS Central Nervous System
CRC Colorectal Cancer
CR Complete Response
ctDNA Circulating Tumor DNA
DoR Duration of Response
EGFR Epidermal Growth Factor Receptor
FDA U.S. Food and Drug Administration
FGFR Fibroblast Growth Factor Receptor
GTP/GDP Guanosine Triphosphate/Guanosine Diphosphate
HER2 Human Epidermal Growth Factor Receptor 2
HER3 Human Epidermal Growth Factor Receptor 3
HNSCC Head and Neck Squamous Cell Carcinoma
HRR Homologous Recombination Repair
H&N Head and Neck
IHC Immunohistochemistry
ILD Interstitial Lung Disease
MAPK Mitogen-Activated Protein Kinase
MEK Mitogen-Activated Protein Kinase Kinase
MSI-H Microsatellite Instability-High
MSS Microsatellite Stable
NCI-MATCH National Cancer Institute Molecular Analysis for Therapy Choice
NGS Next-Generation Sequencing
NRG1 Neuregulin 1
NSCLC Non-Small-Cell Lung Cancer
NTRK Neurotrophic Tropomyosin Receptor Kinase
ORR Objective Response Rate
OS Overall Survival
PARP Poly (ADP-Ribose) Polymerase
PD-1 Programmed Cell Death Protein 1
PD-L1 Programmed Death-Ligand 1
PFS Progression-Free Survival
POLE DNA Polymerase Epsilon
POLD1 DNA Polymerase Delta 1
RET Rearranged During Transfection
RNA Ribonucleic Acid
ROS1 c-ros Oncogene 1 (Receptor Tyrosine Kinase)
SCC Squamous Cell Carcinoma
SCLC Small-Cell Lung Cancer
T-DXd Fam-Trastuzumab Deruxtecan
TKI Tyrosine Kinase Inhibitor
TMB Tumor Mutational Burden
TMB-H Tumor Mutational Burden-High
TRK Tropomyosin Receptor Kinase
WHO World Health Organization