ABC	ATP-binding cassette
ApoE	apolipoprotein E
AUC	area under the curve
BBB	blood–brain barrier
BCRP	breast cancer resistance protein
CBD	cannabidiol
CED	convection-enhanced delivery
CMC	chemistry, manufacturing, and controls
CMT	carrier-mediated transport
CNS	central nervous system
CPP	cell-penetrating peptide
CQA	critical quality attribute
CSF	cerebrospinal fluid
CYP	cytochrome P450
EVS	extracellular vesicles
fu,brain	fraction of unbound drug in brain tissue
fu,p	unbound plasma fractions
FUS	focused ultrasound
GDNF	glial-derived neurotrophic factor
GLUT1	glucose transporter 1
GMP	good manufacturing practice
IPSC	induced pluripotent stem cell
IR	insulin receptor
ISF	interstitial fluid
Km	Michaelis constant
Kd	dissociation constant
Kp,brain	brain-to-plasma partition coefficient
Kp,uu	unbound tissue-to-unbound plasma partition coefficient
Kp,uu,brain	unbound brain-to-unbound plasma partition coefficient
KYNA	kynurenic acid
LAT1	large neutral amino acid transporter 1
LD	linear dichroism
LDL	low-density lipoprotein
LDLR	low-density lipoprotein receptor
LOGD	distribution coefficient
LRP1	low-density lipoprotein receptor-related protein 1
MCT1	monocarboxylate transporter 1
MCTS	monocarboxylate transporters
MRI	magnetic resonance imaging
MRPS	multidrug resistance-associated proteins
NHP	non-human primate
NLCS	nanostructured lipid carriers
NMDA	N-methyl-D-aspartate
NPS	nanoparticles
NR	not reported
NVU	neurovascular unit
P-gp	P-glycoprotein
PAMAM	poly(amidoamine)
PAT	process analytical technology
PBPK	physiologically based pharmacokinetic
PCD	passive cavitation detection
PD	pharmacodynamics
PDEVS	plant-derived extracellular vesicles
PDI	polydispersity index
PEG	polyethylene glycol
PET	positron emission tomography
PK	pharmacokinetics
pKa	acid dissociation constant
PKPD	pharmacokinetic–pharmacodynamic
PLGA	poly(lactic-co-glycolic acid)
QbD	quality by design
QTPP	quality target product profile
RMT	receptor-mediated transcytosis
RVG	rabies virus glycoprotein
SIRNA	small interfering RNA
SLCS	solute carrier transporters
SLNS	solid lipid nanoparticles
SULT	sulfotransferases
TAT	trans-activator of transcription
TEER	transendothelial electrical resistance
TF	transferrin
TFR	transferrin receptor
THC	Δ9-tetrahydrocannabinol
UGT	UDP-glucuronosyltransferases
VEGF	vascular endothelial growth factor
VMAX	maximum transport rate