Table 2.

Study 3101 (Schizophrenia) Least Squares Mean Change from Baseline for Serum Urate for Iloperidone vs Placebo Treatment Groups (μmol/L).

Visit	Iloperidone	Placebo	LS Mean Difference	p-value
	LS Mean Change (SE), n	LS Mean Change (SE), n	(95% CI)
Day 0	318.3 (73.96), 300	313.6 (79.61), 147	-	-
Day 14	15.5 (3.39), 276	−2.98 (4.94), 135	18.5 (6.55. 29.93)	=0.0024
Day 28	28.0 (4.05), 206	4.2 (6.07), 98	23.8 (9.16. 37.96)	=0.0014

Baseline shown as mean (SD). LS mean change shown for each evaluation for serum urate in Study 3101 (Schizophrenia).

ANCOVA analysis of covariance, CI confidence interval, LS least squares, SE standard error, SD, standard deviation

Baseline is defined as the latest non-missing observation across all the visits in the Screening Phase before the first dose of study medication. LS means, CIs, and p-values are based on ANCOVA model with main effects of treatment group and pooled site, and baseline as a covariate. All p values represent the difference between iloperidone and placebo.