Skip to main content
. 2025 Dec 17;56:101027. doi: 10.1016/j.jot.2025.11.003

Fig. 2.

Fig. 2

Asymmetrical myostatin activation of fibro-adipogenic progenitors (FAPs) in PVMs (A) The UMAP plots of main cell types for the PVMs. FAPs = fibro-adipogenic progenitors; SMCs = smooth muscle cells; MuSCs = muscle stem cells. (B) The UMAP plots of main cell types for the PVMs from the concave and convex side. (C) Dot plot of highly expressed genes in each cell type. (D) Percentage of each cell type. (E) UMAP plots of genes marked FAPs. (F) Pathway enrichment analysis of differentially expressed genes in FAPs. (G) Hierarchical clustering heatmap illustrating differentially expressed genes (DEGs) between the concave and convex side of PVMs, with MSTN (myostatin) marked (red arrow). (H)Volcano plot illustrating DEGs between the concave and convex side of the PVMs. (I) Co-localization of Laminin (red), PDGFRα (green), and Myostatin (yellow) on the concave and convex side of the PVMs in patients with AIS. Scale bar: 50 μm. (J) Quantification of data I, n = 5. Paired t-tests, ∗∗p < 0.01.