Table 3.
Comparisons of pharmacokinetic parameters
| Parameters | Units | Geometric mean and ratio | 90%CI of the ratio (%) | ||
|---|---|---|---|---|---|
| Fasting | Fed | Fasting/Fed (%) | |||
| Tmax | h | 1.31 | 1.67 | 78.44 | 49.05~107.46 |
| Cmax | ng/mL | 186.70 | 112.79 | 165.53 | 152.29~178.77 |
| AUC0-t | ng·h/mL | 1305.15 | 950.93 | 137.25 | 127.21~147.29 |
| AUC0-∞ | ng·h/mL | 1331.45 | 977.89 | 136.16 | 125.86~146.45 |
| AUC_%Extrap | % | 1.80 | 2.57 | 70.04 | 44.06~96.16 |
| t1/2 | h | 8.18 | 8.34 | 98.08 | 85.81~110.26 |
| λz | 1/hr | 0.08 | 0.08 | 100.00 | 96.41~107.58 |
Notes: Cmax, maximum plasma concentration. Tmax, time to reach Cmax. AUC0~t, area under time-concentration curve from administration to last observed concentration at time t. AUC0-∞, area under time-concentration curve from administration extrapolated to infinity. AUC_%Extrap, percentage of residual area of AUC. t1/2, terminal half-life. λz, elimination rate constant. CI, confidence interval