Table 1.
Association of MTHFD2 levels with clinicodemographic parameters in patients with OSCC
| Characteristics | Cases | MTHFD2 staining score | P value | |
|---|---|---|---|---|
| Low | High | |||
| Age | ||||
| ≥ 50 | 28 | 4 | 24 | 0.028 |
| < 50 | 17 | 3 | 14 | |
| Sex | ||||
| Male | 30 | 4 | 26 | 0.898 |
| Female | 15 | 3 | 12 | |
| T-primary tumor | ||||
| T1- T2 | 25 | 6 | 19 | < 0.001 |
| T3 -T4 | 20 | 1 | 14 | |
| N-regional lymph node | 0.043 | |||
| Non-metastasis | 26 | 7 | 19 | |
| Metastasis | 19 | 0 | 19 | |
| Histological grade | ||||
| Well differentiated | 30 | 6 | 24 | 0.070 |
| Moderately + poorly differentiated | 15 | 1 | 14 | |
| TNM stage | ||||
| I - II | 18 | 6 | 12 | 0.002 |
| III - IV | 27 | 1 | 26 | |
| Ki67 | ||||
| High | 37 | 21 | 16 | 0.047 |
| Low | 8 | 1 | 7 | |
T, tumor; N, node