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. 2005 Nov 24;33(20):6555–6565. doi: 10.1093/nar/gki964

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© The Author 2005. Published by Oxford University Press. All rights reserved

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hBex2 regulates the transcriptional activity of oligomeric DNA-binding complex containing LMO2 and NSCL2. Human Bex2 binds to LMO2 as part of the oligomeric complex that binds to the E-box motif-containing sequence. This interaction may regulate the transcriptional activity of LMO2 through its binding to NSCL2 and LDB1 during the formation of DNA-binding complex. The stoichiometry of the complex is unknown, but the E-box-binding modules of the oligomeric complex are provided by at least one molecule of NSCL2. The other half-E-motif-binding protein may also be NSCL2, or other bHLH proteins. hBex2, LMO2, NSCL2 and LDB1 form a complex at the E-box site and regulate specific gene expression.