Table 3.
Risk Factor Associated with Recurrence of Rectal Neuroendocrine Tumor (ver. Mitosis)
| Parameter | Comparison | Univariable analysis | Multivariable analysis | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | |||
| ESD | Done vs not done | 0.89 (0.27–2.99) | 0.85 | |||
| EMR | Done vs not done | 1.63 (0.43–6.06) | 0.46 | |||
| Endoscopic size | 0.91 (0.72–1.16) | 0.47 | ||||
| Pathologic size | 1.13 (0.92–1.39) | 0.23 | 1.12 (0.86–1.46) | 0.41 | ||
| Grade | 2 vs 1 | 23.60 (5.32–104.68) | <0.001 | |||
| Mitosis | 0.001 | 0.008 | ||||
| 2–20 vs <2 (/HPF) | 23.65 (1.86–300.50) | 0.01 | 20.88 (1.61–270.19) | 0.02 | ||
| >20 vs <2 (/HPF) | 11.19 (1.58–79.31) | 0.01 | 7.93 (0.90–69.87) | 0.07 | ||
| EUS depth | 0.58 | |||||
| SM vs MM | 3.85 (0.04–356.15) | 1.00 | ||||
| PM vs SM | 5.16 (0.03–813.78) | 0.93 | ||||
| CCI | 0.59 | |||||
| 1 vs 0 | 1.37 (0.25–7.66) | 1.00 | ||||
| 2 vs 0 | 1.99 (0.43–9.15) | 0.62 | ||||
HR, hazard ratio; CI, confidence interval; ESD, endoscopic submucosal dissection; EMR, endoscopic mucosal resection; HPF, high-power field; EUS, endoscopic ultrasonography; SM, submucosal; MM, muscularis mucosae; PM, muscularis propria; CCI, Charlson Comorbidity Index.