TABLE 2.
Demographic and clinical characteristics of the sample depending on the carriage of polymorphic variants of CYP2C19*2, CYP2C19*17, type of CYP2C19 metabolism.
| Variables | CYP2C19*2 | p | CYP2C19*17 | p | CYP2C19 metabolism | p | |||
|---|---|---|---|---|---|---|---|---|---|
| GG (n = 85) | GA + AA (n = 27) | CC (n = 69) | CT + TT (n = 43) | Normal (n = 78) | Intermediate (n = 26) | ||||
| Age, years (Me [Q1; Q3]) | 15 [14; 16] | 14 [13,2; 15] | 0.112 | 15 [14; 16] | 14 [14; 15] | 0.348 | 15 [14; 16] | 14 [14; 15] | 0.157 |
| Height, m (Me [Q1; Q3]) | 1.64 [1.59; 1.69] | 1.62 [1.58; 1.68] | 0,5 | 1.64 [1.58; 1.68] | 1.64 [1.59; 1.69] | 0.728 | 1.64 [1.59; 1.68] | 1.63 [1.58; 1.68] | 0.646 |
| Weight, kg (Me [Q1; Q3]) | 54.25 [49; 63,7] | 49,1 [43,62; 61,13] | 0.241 | 54.4 [48.42; 63.5] | 53,5 [46,3; 61] | 0.225 | 54.35 [49.53; 64.0] | 51.0 [44.0; 63.0] | 0.390 |
| BMI (Me [Q1; Q3]) | 20.18 [18.61; 23,25] | 19.05 [17.44; 21.24] | 0.118 | 19.88 [18,44; 22,42] | 20 [17,47; 22,21] | 0.204 | 20.62 [18,76; 23.39] | 19.15 [17,48; 21,5] | 0.164 |
| Total number of hospitalizations (including the current one) (Me [Q1; Q3]) | 1 [1; 1] | 1 [1; 1] | 0.419 | 1 [1; 1] | 1 [1; 1] | 0.398 | 1 [1; 1] | 1 [1; 1] | 0.454 |
| Age of onset of symptoms of mental disorder, years (Me [Q1; Q3]) | 13 [12; 14] | 13 [12; 14] | 0.582 | 13 [12; 14] | 13 [12; 14] | 0.567 | 13 [12; 14] | 13 [12; 14] | 0.570 |
| Age of occurrence of NSSI, years (Me [Q1; Q3]) | 14 [13; 14] | 13 [12; 14.75] | 0.691 | 14 [12,5; 15] | 13 [12; 14] | 0.316 | 14 [13; 14] | 13 [12; 15] | 0.556 |
| Total number of suicide attempts (Me [Q1; Q3]) a | 0 [0; 1] | 0 [0; 1] | 0.96 | 0 [0; 1] | 0 [0; 1] | 0.814 | 0 [0; 1] | 0 [0; 1] | 0.878 |
| Age at the start of taking antidepressants, years (Me [Q1; Q3]) | 15 [14; 16] | 14,5 [13,25; 15] | 0.422 | 15 [14; 16] | 14 [14; 15] | 0.132 | 15 [14; 16] | 15 [14; 15] | 0.489 |
| Duration of mental disorder before inclusion in the study, months (Me [Q1; Q3]) | 19,5 [10,25; 27] | 14 [5.25; 31,5] | 0.5 | 18 [8,5; 28,5] | 20 [10; 27] | 0.864 | 18 [10; 27] | 16 [5; 32] | 0.724 |
| Male, n (%) | 6 (7,1%) | 5 (18,5%) | 0.081 | 10 (14,5%) | 1 (2,3%) | 0.035 | 6 (7,7%) | 5 (19,2%) | 0.137 |
| Female, n (%) | 79 (92,9%) | 22 (81,5%) | 59 (85,5%) | 42 (97,7%) | 72 (92,3%) | 21 (80,8%) | |||
| Suicidal thoughts, n (%) | 78 (91,8%) | 27 (100%) | 0.124 | 64 (92,8%) | 41 (95,3%) | 0.581 | 72 (92,3%) | 26 (100%) | 0.333 |
| A history of NSSI, n (%) | 79 (92,9%) | 22 (92,6%) | 0.821 | 66 (95,6%) | 39 (90,7%) | 0.428 | 74 (94,9%) | 24 (92.3%) | 0.756 |
| History of suicide attempt, n (%) | 37 (43,5%) | 11 (40,7%) | 0.799 | 30 (43,5%) | 18 (41,9%) | 0.866 | 34 (43,6%) | 11 (42,3%) | 0.909 |
BMI, body mass index.
a
n = 48.