Figure 3.

PYM binds Mago–Y14 with extensive interactions. (A) Schematic view of the PYM–Mago–Y14 complex (left panel) and schematic diagram highlighting the key residues involved in the interaction (right panel). Positively charged residues of PYM interact with negatively charged residues of Mago helices α1 and α2. In addition, PYM interacts with the β2–β3 loop of Y14 by means of hydrophobic contacts. Colours are as in Fig 2. Hydrogen bonds are shown with dotted lines. (B) Stereo representation of the structure and of the interacting residues in a similar orientation as in Figs 2A,3A.