Table 2.
Example |
||||
---|---|---|---|---|
Protein name | Bacterial genomes | Archaeal genomes | Genome | Sec location (protein length) |
Known selenoproteins | ||||
Formate dehydrogenase α-chain | 37 | 3 | Methanococcus jannaschii | 144 (686) |
Formylmethanofuran dehydrogenase, subunit B | 0 | 2 | Methanococcus jannaschii | 121 (435) |
Coenzyme F420-reducing hydrogenase, α-subunit | 0 | 3 | Methanococcus jannaschii | 389 (413) |
Methylviologen-reducing hydrogenase, α-subunit | 3 | 2 | Methanococcus jannaschii | 441 (464) |
Coenzyme F420-reducing hydrogenase, δ-subunita | 2 | 3 | Methanococcus jannaschii | 13,64 (134) |
Heterodisulphide reductase, subunit A | 1 | 2 | Methanococcus jannaschii | 207 (668) |
Selenophosphate synthetase | 17 | 2 | Methanococcus jannaschii | 19 (349) |
Peroxiredoxin (Prx) | 2 | 0 | Eubacterium acidaminophilum | 47 (203) |
Glycine reductase complex, selenoprotein Ab | 9 | 0 | Clostridium difficile | 45 (157) |
Glycine reductase complex, selenoprotein B | 8 | 0 | Clostridium difficile | 350 (436) |
Proline reductase | 3 | 0 | Clostridium difficile | 151 (241) |
New selenoproteins | ||||
HesB-like protein | 5 | 1 | Methanococcus jannaschii | 35 (95) |
Thioredoxin (Trx) | 4 | 0 | Treponema denticola | 32 (107) |
Prx-like thiol:disulphide oxidoreductase | 3 | 0 | Geobacter sulfurreducens | 66 (209) |
SelW-like protein | 3 | 0 | Campylobacter jejuni | 12 (81) |
Glutathione peroxidase | 1 | 0 | Treponema denticola | 35 (155) |
Candidate selenoproteins | ||||
Glutaredoxin (Grx) | 1 | 0 | Geobacter sulfurreducens | 49 (122) |
Protein similar to the N-terminal domain of Prx reductase AhpF | 1 | 0 | Carboxydothermus hydrogenoformans | 147 (218) |
Thiol:disulphide interchange protein | 1 | 0 | Geobacter metallireducens | 33 (190) |
DsbG-like protein | 1 | 0 | Chloroflexus aurantiacus | 104 (253) |
Fe–S oxidoreductase | 1 | 0 | Desulfovibrio vulgaris | 244 (432) |
DsrE-like protein | 1 | 0 | Desulfovibrio vulgaris | 70 (107) |
NADH oxidase | 1 | 0 | Geobacter metallireducens | 45 (451) |
Distant homologue of peroxidase/peroxynitrite reductase system component AhpD | 1 | 0 | Geobacter sulfurreducens | 50 (98) |
A total of 11 previously known prokaryotic selenoproteins are shown, along with five new selenoproteins (supported by occurrences in multiple genomes and the presence of potential SECIS elements) and eight candidate selenoproteins (supported by occurrences in single genomes and the presence of potential SECIS elements). The number of bacterial and archaeal genomes in which indicated selenoproteins were found is shown, followed by names of representative genomes (full list is in supplementary Fig S1 online) and Sec locations and lengths of representative selenoproteins.
a Contains two Sec residues.
b Protein was not detected in genomic searches.