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. 2004 Apr 23;5(5):453–458. doi: 10.1038/sj.embor.7400155

Figure 3.

Figure 3

Recent developments in our understanding of messenger RNA export in Saccharomyces cerevisiae. During transcription, mRNA export factors are recruited to the precursor mRNA. The helicase Dbp5 interacts with components of the transcription factor complex IIH (TFIIH). Sus1 tethers some mRNAs to the nuclear pore complex (NPC) with Sac3 and Thp1 during transcription, through its association with the Spt/Ada/Gcn5/acetyltransferase (SAGA) complex. The transcription and export (TREX) complex consists of Sub2, Yra1 and the THO complex, which functions in transcription and elongation. Yra1 and Npl3 recruit Mex67, which docks the mRNA through Mtr2 to the NPC. Nab2 interacts with Mlp proteins, which act as an mRNA quality control checkpoint before the translocation of the messenger ribonucleoprotein complexes. Apart from Npl3, two novel SR-type mRNA-binding proteins, Gbp2 and Hrb1 are part of the exported mesenger ribonucleoprotein (mRNP) complex. CBC, cap-binding complex.