Figure 2.

Plausible scenarios for long-range transduction of p75 signalling complexes. (A) Internalization of p75 with ligand to the recycling endosome (upper) or cleavage of p75 to release the intracellular domain (lower) may be followed in both cases by recruitment of intracellular interactors with nuclear localization signals. These might then serve as adaptors to link the p75 signalling complexes to an importin/dynein retrograde transport ensemble on the microtubules. (B) In the case of a sortilin-containing complex in the somatodendritic compartment, internalization and rapid translocation to the Golgi may be mediated by sorting signals in the cytoplasmic tail of sortilin. The complex might then transfer to lysosomes or, after dissociation, specific components might enter the anterograde pathway for recycling to the cell surface.