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The asymmetric accumulation of Ash1 represses HO in daughters. ASH1 mRNA is recognized by Loc1 and She2 and transported in the cytoplasm, where it is coupled to the other She proteins to form the ribonucleoprotein (RNP; ASH1 mRNA/She2/She3/Myo4). The RNP is transported along the actin cables to the distal tip, where the anchoring and translation of ASH1 mRNA occurs. Finally, Ash1 enters the daughter nucleus, where it represses HO.
