Table 1.
Sequence features of members of the human protein disulphide isomerase family
| Name* | SwissProt accession | Length | ER retention | N-glycosylation sites (putative) | a-like domains | Charge pair sequence | Conserved arginine |
|---|---|---|---|---|---|---|---|
| PDI | P07237 | 508 | KDEL | 0 | 2 | E47–K81, E391–K424 | Yes, yes |
| ERp57 | P30101 | 505 | QEDL | 0 | 2 | E51–K82, E400–K433 | Yes, yes |
| PDIp | Q13087 | 525 | KEEL | 3 | 2 | E65–K99, K412–E445 | Yes, yes |
| ERp72 | P13667 | 645 | KEEL | 0 | 3 | E85–K119, E200–K234, E549–K582 | Yes, yes, yes |
| ERp65 | Q8N807 | 584 | KEEL | 8 | 2 | L66–K100, M411–K444 | No, no |
| ERp27 | Q96DN0 | 273 | KVEL | 1 | 0 | – | – |
| PDIr | Q14554 | 519 | KEEL | 0 | 3 | M176–N209, M299–A334, M420–A453 | No, yes, no |
| ERp28 | P30040 | 261 | KEEL | 1 | 0 | – | – |
| ERdj5 | Q8IXB1 | 793 | KDEL | 1 | 4 | N152–A183, D474–T505, D582–S613, D694–K725 | Yes, no, yes, yes |
| P5 | Q15084 | 440 | KDEL | 0 | 2 | E49–A80, E184–A219 | Yes, yes |
| ERp18 | O95881 | 172 | EDEL | 1 | 1 | I60–N93 | No |
| ERp44 | Q9BS26 | 406 | RDEL | 0 | 1 | N52–R89 | Yes |
| ERp46 | Q8NBS9 | 432 | KDEL | 0 | 3 | M83–K118, K211–K244, K344–E378 | Yes, yes, yes |
| TMX | Q9H3N1 | 280 | Unknown | 0 | 1 | E50–K82 | Yes |
| TMX2† | Q9Y320 | 296 | KKDK | 2 | 1 | E161–K193 | ?‡ |
| TMX3 | Q96JJ7+ | 454 | KKKD | 2 | 1 | D47–K81 | Yes |
| TMX4 | Q9H1E5 | 349 | Unknown | 1 | 1 | K58–K90 | No |
*This table lists the 17 human protein disulphide isomerase (PDI)-family members the endoplasmic reticulum (ER) location of which has been confirmed. In addition, Q96MT2 is probably an ER-located human PDI-family member.
†The version of TMX2 included here represents the consensus version from human cDNA databases and is consistent with homologous proteins found in a wide range of species. A longer version of TMX2 (Q8NBP9, 372 amino acids, of which the first 281 are identical to the sequence listed here) has been published (Meng et al, 2003).
‡The alignment of TMX2 with other family members in this region is ambiguous. It is possible that the conserved arginine is present in the sequence.
+TMX3 starts at M33 of Q96JJ.