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Model for the evolution of RNA editing. (A) A nucleotide-incorporating enzyme is present as a pre-existing editing activity in the cell. (B) A mutation in a gene leads to the transcription of a (t)RNA molecule that has to be edited to regain its function. (C) The pre-existing activity is promiscuous and accepts the inactive transcript as a new substrate and restores its function. Thereby, an RNA-editing event is established.
