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. 2005 Apr 15;6(5):458–463. doi: 10.1038/sj.embor.7400390

Figure 2.

Figure 2

WPRE-mediated release of mutant transcripts to the cytoplasm of myoblasts. Myoblasts expressing the mutant UTR(200) construct produced transcripts (shown as red foci), which were localized mainly in the nucleus after staining with DAPI. The presence of WPRE downstream of the mutant DMPK 3′ UTR (UTR(200W)) released most of the transcripts in the cytoplasm. No RNA foci were detected in cells expressing the wild-type UTR(wt) construct, whereas the presence of the antisense form of WPRE (UTR(200W-AS)) did not stimulate the export of the transcript to the cytoplasm. Scale bar, 0.25 mm.