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. 2026 Feb 7;29(3):114950. doi: 10.1016/j.isci.2026.114950

Figure 5.

Figure 5

SMR and colocalization analyses of CD40 and MSG IFN-associated genes in SD

(A) The left panel depicts SMR results showing the association between CD40 expression and SD GWAS (P SMR multi < 0.05; HEIDI test p > 0.01), whereas the right panel displays a locus comparison of CD40 cis-eQTL and CCL4 GWAS via colocalization (PPH4 > 0.5).

(B) SMR results showing the association between APOBEC3G expression and SD GWAS and locus comparisons of APOBEC3G cis-eQTL with Flt3L and DNER GWAS via colocalization.

(C) SMR results showing the association between IFI27L2 expression and SD GWAS and locus comparison of IFI27L2 cis-eQTL and NGF-β GWAS via colocalization.

(D) SMR results showing the association between TMEM50B expression and SD GWAS and locus comparison of TMEM50B cis-eQTL and IL-1α GWAS via colocalization. Statistical analysis: SMR significance criteria: P_SMR_multi < 0.05, HEIDI test p > 0.01. Data sources: blood eQTL (eQTLGen, N = 31,684), MSG eQTL (GTEx V8, N = 144), inflammatory cytokines GWAS, and SD GWAS (FinnGen R10). Colocalization: coloc R package, PPH4 > 0.5 indicates shared causal variants.