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. 2002 Oct;13(10):3588–3600. doi: 10.1091/mbc.E02-03-0145

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Copyright © 2002, The American Society for Cell Biology

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Confocal microscopy of primary embryonic fibroblasts. (A and B) Fluorescence pattern of acidic LysoTracker Red-positive compartments is shown in wild-type (A) and Snx1^-/-; Snx2^-/- (B) primary embryonic fibroblasts. (C and D) Distribution of fluorescent transferrin is shown in wild-type (C) and Snx1^-/-; Snx2^-/- (D) fibroblasts after 15 min of endocytic uptake. (E and F) Distribution of fluorescent LDL is shown in wild-type (E) and Snx1^-/-; Snx2^-/- (F) fibroblasts after 40 min of endocytic uptake. Bars, 20 μm.