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RhoA activation reverses inhibition by 70Ten. NIH 3T3 fibroblasts treated with LPA and Rat-1 fibroblasts expressing constitutively active RhoA or control DNA were incorporated into a fibrin-FN + 70Ten matrix. Contraction data are expressed as the mean ± SEM of duplicate experiments. Compared with untreated cells, the addition of LPA or expression of active RhoA significantly increased contraction of matrices (★p < 0.05; Student's paired t test).
