Table 3.

Guidelines for conditioning regimens before HSC transplantation

Cyclophosphamide 50 mg/kg for 4 days at a 1-h infusion from days -5

to -2 before the transplantation; this is standard treatment for

aplastic anaemia. Antithymocyte globulin may or may not be added

Cyclosphamide 60 mg/kg for 2 days at 1-h infusion followed by total

body irradiation, as currently used at the treating centre

Busulfan 16 mg/kg orally over 4 days in 16 doses of 1 mg/kg each,

followed by cyclophosphamide 60 mg/kg a 1-h infusion for 2 days;

anticonvulsant prophylaxis is required

Combination chemotherapy: BEAM (BCNU 300 mg/m2 intravenously

day -7; VP-16 250 mg/m2 per day, divided over two doses each

day, from days -7 to -4; Ara-C 200 mg/m2 per day, divided over

two doses each day, on days -7, -6 and -4; melphalan 140

mg/m2 intravenously on day -3)