Table 1.

Mutations introduced into the predicted PEST sequence of CFTR

Mutant	Sequence	PEST Score
Wild-type (WT)	716 – KTPLQMNGIEEDSDEPLER – 734	+6.91
Poly-Valine	716 – KTPLQMNGIVVVVVVPLER – 734	-26.19
E725K/E726K	716 – KTPLQMNGIKKDSDEPLER – 734	N/A
S728A	716 – KTPLQMNGIEEDADEPLER – 734	+4.07
T717A/E725K	716 – KAPLQMNGIKEDSDEPLER – 734	N/A

* Residues in bold are the mutations introduced.