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. 2026 Mar 17;17(3):662–678. doi: 10.7150/jca.130519

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DNA methylation, protein-protein interaction network, and subcellular localization of CHID1. (A) Heatmap showing the DNA methylation patterns of CHID1-associated CpG sites in GBM samples, with clinical annotations displayed above the heatmap. Color gradients represent relative methylation levels across samples. (B) Protein-protein interaction (PPI) network of CHID1 and related proteins constructed using STRING, illustrating the functional associations among members of the chitinase-like family and interacting proteins. (C) Immunofluorescence images showing the subcellular localization of CHID1 protein in human cells obtained from the Human Protein Atlas database. Green indicates CHID1 staining, red represents cytoskeletal structures, and blue denotes nuclear staining (DAPI). Merged images and magnified views highlight the cellular distribution of CHID1.