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. 2026 Mar 17;17(3):662–678. doi: 10.7150/jca.130519

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Gene Ontology enrichment and functional interaction network associated with CHID1-related genes in GBM. (A) Gene Ontology (GO) enrichment analysis of CHID1-associated genes, including Biological Process (BP), Molecular Function (MF), and Cellular Component (CC) categories. The bubble plots display significantly enriched terms such as oxidative phosphorylation, cellular respiration, ATP metabolic process, ribosomal structure, and mitochondrial components. Bubble size represents gene counts and color indicates statistical significance. (B) Chord diagram illustrating the relationships between enriched GO biological processes and their corresponding genes. The network highlights strong associations with mitochondrial respiration, ATP synthesis-coupled electron transport, cytoplasmic translation, and oxidative phosphorylation, indicating that CHID1-related genes are closely linked to cellular energy metabolism and mitochondrial function.