Figure 7.

MetaCore pathway enrichment analysis of genes associated with CHID1 expression in GBM. (A) Bar plot showing top 20 significantly enriched biological pathways associated with CHID1-related genes identified in GBM. Pathways are ranked according to -log(p-value), highlighting processes involved in protein folding and amyloid precursor protein processing, oxidative stress response, DNA replication and cell-cycle regulation, cytoskeleton remodeling, immune response, chemotaxis signaling, DNA damage response, and apoptosis-related pathways. (B) Representative MetaCore pathway map illustrating the regulation of amyloid precursor protein (APP) processing and amyloid-beta metabolism. The network depicts interactions among key enzymes and regulatory proteins involved in APP cleavage, including ADAM family proteases, BACE1/BACE2, and the γ-secretase complex, which generate different APP cleavage fragments. The pathway also highlights downstream signaling events related to amyloid-beta production, neuronal apoptosis, transcriptional regulation, and synaptic plasticity, suggesting that CHID1-associated gene networks may participate in pathways linked to neurodegeneration-related processes, oxidative stress signaling, and cell survival mechanisms.