Figure 8.

Single-cell transcriptomic analysis of CHID1 expression across glioma cellular populations. (A, B) UMAP visualization of single-cell RNA-seq data showing major cellular populations in glioma, including glioma cells, myeloid cells, T cells, B cells, oligodendrocytes, endothelial cells, pericytes, and other minor populations. The right panel shows the distribution of CHID1 expression projected onto the UMAP embedding. (C) Violin plots showing CHID1 expression levels across different cell types and glioma subtypes. Statistical comparisons between groups are indicated (**** p < 0.0001; ns, not significant). (D) Heatmap showing the expression of canonical marker genes across annotated cell populations, confirming the identity of major cell types. Additional annotations indicate tumor type (recurrent GBM, GBM, oligodendroglioma, and astrocytoma) and tumor grade. Expression values are shown as Z-scores.