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. 2026 Mar 17;17(3):662–678. doi: 10.7150/jca.130519

Figure 9.

Figure 9

Drug sensitivity correlation and molecular docking analysis of CHID1-associated compounds. (A) Correlation analysis between CHID1 mRNA expression and drug sensitivity in the CTRP dataset. Bubble size represents -log10(FDR) significance, while color indicates the strength and direction of correlation. (B) Correlation between CHID1 expression and drug response in the GDSC dataset, highlighting potential therapeutic compounds associated with CHID1 expression levels. (C-E) Three-dimensional molecular docking models illustrating the predicted binding interactions between CHID1 and selected candidate compounds: (C) (5Z)-7-Oxozeaenol, (D) Trametinib, and (E) Selumetinib. The ligand molecules are shown within the predicted binding pocket of the protein. (F-H) Two-dimensional interaction diagrams showing detailed residue-ligand interactions for (F) (5Z)-7-Oxozeaenol, (G) Trametinib, and (H) Selumetinib, including hydrogen bonds, hydrophobic contacts, and other non-covalent interactions, suggesting potential binding affinity between these compounds and CHID1.