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. 2026 Mar 17;17(3):662–678. doi: 10.7150/jca.130519

Table 1.

Gene annotation and genomic features of chitinase and chitinase-like family members.

Gene Symbol Gene Name Gene ID Description Chromosome Location Synonyms
CHI3L1 Chitinase 3-like 1 1116 CHI3L1 (chitinase 3-like 1) is a protein coding gene. Diseases associated with CHI3L1 include asthma-related traits 7 and schizophrenia. Among its related pathways are innate immune system and mammary gland development pathway - Involution. 1q32.1 GP39; YKL40; YK-40
CHI3L2 Chitinase 3-like 2 1117 CHI3L2 (chitinase 3-like 2) is a protein coding gene. Diseases associated with CHI3L2 include frontotemporal dementia and/or amyotrophic lateral sclerosis 1 and frontotemporal dementia and/or amyotrophic lateral sclerosis. 1q32.1 YKL-39
CHIA Chitinase acidic 27159 CHIA (chitinase acidic) is a protein coding gene. Diseases associated with CHIA include asthma and Gaucher's disease. Among its related pathways are digestion and absorption. 1p13.2 AMCase; TSA1902; CHIT2
CHID1 Chitinase domain containing 1 66005 CHID1 (chitinase domain containing 1) is a protein coding gene. Among its related pathways is response to elevated platelet cytosolic Ca2+. 11p15.5 MGC3234; FLJ42707; SI-CLP
CHIT1 Chitinase 1 1118 CHIT1 (chitinase 1) is a protein coding gene. Diseases associated with CHIT1 include chitotriosidase deficiency and acid phosphatase deficiency. Among its related pathways are digestion and absorption and innate immune system. 1q32.1 CHIT; CHI3