Table 1:

Demographic and clinical characteristics of patients in the bulk-sequenced (Cohort 1, n = 15) and single cell-sequenced (Cohort 2, n = 10) cohorts. Age is reported as the mean with range, while categorical variables (Race, FIGO 2018 Stage, Node Positive, Histology, Therapy, and Status) are presented as numbers with corresponding percentages.

	Cohort 1		Cohort 2
Enrollment period	2016-2018		2019-2021
Analytical Platform	Bulk RNA sequence		Single-cell RNA sequence
Number of patients	15		10
Age (mean, range)	55.7 years, 32-79 years		48.1 years, 32-77 years
Race
Black	4 (26.7%)		0 (0%)
Caucasian	11 (73.3%)		10 (100%)
FIGO 2018 Stage
I	3 (20%)		2 (20%)
II	2 (13.3%)		3 (30%)
III	10 (66.7%)		3 (30%)
IV	0		2 (20%)
Node Positive *
Yes	11 (73.3%)		4 (40%)
No	4 (26.7%)		6 (60%)
Histology
Adenocarcinoma	3 (20%)		2 (20%)
Clear Cell	0 (0%)		1 (10%)
Poorly Differentiated	1 (6.7%)		0 (0%)
Squamous	11 (73.3%)		7 (70%)
Therapy
Curative	15 (100%)		8 (80%)
Palliative	0 (0%)		2 (20%)
Status
AWD	1 (6.7%)		5 (50%)
DOD	4 (26.7%)		1 (10%)
NED	10 (66.7%)		4 (40%)
Time points	Pre-RT	On-RT	Pre-RT	On-RT#1	On-RT#2
Number of samples	15	15	10	4	4

Abbreviations: FIGO, International Federation of Gynecology and Obstetrics; AWD, Alive with Disease; DOD, Died of Disease; NED, No Evidence of Disease.

^*Node Positive indicates the presence of lymph node involvement.