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. 2000 Jul;79(1):80–93. doi: 10.1016/S0006-3495(00)76275-8

Three-dimensional Poisson-Nernst-Planck theory studies: influence of membrane electrostatics on gramicidin A channel conductance.

A E Cárdenas 1, R D Coalson 1, M G Kurnikova 1
PMCID: PMC1300917  PMID: 10866939

Abstract

A recently introduced real-space lattice methodology for solving the three-dimensional Poisson-Nernst-Planck equations is used to compute current-voltage relations for ion permeation through the gramicidin A ion channel embedded in membranes characterized by surface dipoles and/or surface charge. Comparisons to a variety of experimental results, presented herein, have proven largely successful. Strengths and weaknesses of the method are discussed.

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Selected References

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