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. Author manuscript; available in PMC: 2026 Mar 25.
Published in final edited form as: Am J Physiol Renal Physiol. 2026 Feb 27;330(4):F456–F466. doi: 10.1152/ajprenal.00414.2025

Table 2.

Changes in Hydration-Related Variables

Variables YF (n = 17) OF (n = 9) Main effects
BH MH BH MH Age Cond Age*Cond
Thirst 2.4±2.5 6.6±2.5 2.4±1.5 6.6±2.3 0.98 <0.001 0.95
Body Mass (kg) 59.1±10.3 59.0±10.2 58.6±8.1 58.0±8.4 0.86 0.13 0.16
CH2O (mL/min) −0.53±0.50 −1.29±0.97 −0.48±0.29 −0.73±0.14 0.20 0.001 0.08
Spot USG 1.015±0.006 1.022±0.004 1.012±0.006 1.022±0.004 0.54 <0.0001 0.41
24-hr USG 1.012±0.004 1.018±0.003 1.011±0.002 1.017±0.004 0.46 <0.0001 0.92
24-hr Urine Osmolality (mOsm/kg H2O) 462±132 681±127 436±88 669±158 0.71 <0.0001 0.75
Plasma Osmolality (mOsm/kg H2O) 287±5 290±5 297±4 300±4 <0.0001 <0.01 0.95
Urine Creatinine (mg/dL) 98±52 127±45 117±83 117±52 0.78 0.36 0.35
Serum Creatinine (mg/dL) 0.80±0.24 0.86±0.18 0.74±0.15 0.72±0.33 0.29 0.86 0.59
Urine Na+ (mmol/24hr) 149±103 121±49 111±35 98±28 0.16 0.28 0.71
Serum Na+ (mmol/L) 141.5±1.5 141.7±1.4 142.9±2.4 144.1±1.7 <0.01 0.18 0.35
Serum K+ (mmol/L) 4.0±0.3 4.0±0.3 4.2±0.5 4.0±0.4 0.43 0.46 0.42
Serum Cl− (mmol/L) 103.9±2.5 106.2±2.2a 106.7±1.8b 106.6±2.3 0.06 0.07 0.045

BH, baseline hydration condition; MH, mild hypohydration condition; CH2O, free water clearance; USG, urine specific gravity.

a

Different from BL,

b

Different from YF