Key Points: Glanzmann Thrombasthenia

GT is a severe inherited platelet function disorder with a high risk of hemorrhage during delivery and postpartum, despite supportive therapy. Miscarriage and antepartum bleeding are not increased, but invasive procedures (amniocentesis, CVS, D&C) carry an elevated bleeding risk. Postpartum hemorrhage occurs in >50% of pregnancies and is the highest-risk period. Platelet transfusions should be avoided unless necessary due to risk of HLA or αIIbβ3 alloimmunization and future refractoriness. Recombinant activated factor VII (rFVIIa) is a key hemostatic agent, particularly in alloimmunized patients or when platelets are ineffective. Delivery should occur at a specialized center with multidisciplinary planning and access to matched platelets, rFVIIa, TXA, and neonatal support. Avoid vacuum-assisted delivery; forceps may be considered only if urgently required. Neonatal risk includes inherited GT and alloimmune thrombocytopenia; early pediatric involvement and monitoring are essential.